Objective: To investigate the prescription rules of professor JIANG Liang-duo for treatment of chronic hepatitis B

explore the new prescriptions for chronic hepatitis B

and provide new thought on its prevention and treatment. Method: Retrospective research was used to collect professor JIANG's outpatient prescriptions for the treatment of chronic hepatitis B and establish a relevant database. Then the professor JIANG's prescription rules for the treatment of this disease were explored through Traditional Chinese Medicine Inheritance Support Platform(TCMISP). Result: A total of 160 prescriptions for chronic hepatitis B were screened

and the results showed 61 kinds of common herbs in professor JIANG Liang-duo's prescriptions for the disease

including Paeoniae Rubra Radix

Paeoniae Alba Radix

Bitter Orange

Malt

et al. A total of 116 core combinations were obtained

including 43 pair herbal combinations

46 triangle herbal combinations

and 27 combinations with four or more herbs. At the same time

evolutionary method was used to achieve 12 new prescriptions for the treatment of chronic hepatitis B. Conclusion: Based on TCMISP

the data mining methods such as text mining and association rules better reflected the prescription rules of JIANG Liang-duo for treatment of chronic hepatitis B

namely:good at using triangle herbal combinations

with lighter and thinner drugs

and mainly based on liver softening and soothing principles to propose differentiation treatment from the state

and pay attention to strengthening the body resistance and eliminating pathogenic factors.