Preparation and Quality Standard of Standard Decoction of Scutellariae Radix

LI Qi; ZHANG Jun; CUI Wen-jin; CHEN Shi-tao; CHENG Jin-tang; LIU An

doi:10.13422/j.cnki.syfjx.2017070036

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Preparation and Quality Standard of Standard Decoction of Scutellariae Radix

更新时间：2024-01-04

- Preparation and Quality Standard of Standard Decoction of Scutellariae Radix
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 7, Pages: 36-40(2017)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2017070036
  CLC： R283.6;R286.0
- Published：2017
- 稿件说明：
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LI Qi, ZHANG Jun, CUI Wen-jin, et al. Preparation and Quality Standard of Standard Decoction of Scutellariae Radix[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(7): 36-40.
DOI：

LI Qi, ZHANG Jun, CUI Wen-jin, et al. Preparation and Quality Standard of Standard Decoction of Scutellariae Radix[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(7): 36-40. DOI： 10.13422/j.cnki.syfjx.2017070036.

摘要

目的：制备黄芩饮片标准汤剂并建立其质量标准，为相关药物的研究与开发提供参考。方法：根据中药饮片标准汤剂制备原则制备黄芩饮片标准汤剂，计算黄芩苷的转移率和出膏率，建立黄芩饮片标准汤剂质量标准，流动相0.2%磷酸水溶液（A）-甲醇（B）梯度洗脱（0~20 min，47% B；20~40 min，47%~87% B），柱温40℃，流速1 mL·min-1，检测波长280 nm。结果：在所建立的制备条件下，黄芩苷转移率55.1%~82.2%，出膏率28.6%~43.8%，pH 4.5~5.5。15批黄芩饮片标准汤剂指纹图谱与对照指纹图谱的相似度均>0.9。结论：建立的制备方法稳定，质量标准完善，适用于黄芩饮片标准汤剂的质量评价。对标准汤剂而言，固定原料能够获得稳定性更好的产品。

Abstract

Objective: To prepare standard decoction of Scutellariae Radix and establish its quality standard. Method: According to the standard of Chinese herbal medicine decoction preparation principle

standard decoction of Scutellariae Radix was prepared to calculate its transfer rate of baicalin and the dry extract rate.In addition

the quality standard of standard decoction of Scutellariae Radix was also established. Result: Transfer rate of baicalin ranged from 55.1% to 82.2%

dry extract rate was at the range of 28.6%-43.8% and pH value was at the range of 4.5-5.5.The fingerprint similarities of 15 batches of standard decoction of Scutellariae Radix with reference fingerprint were >0.9. Conclusion: The preparation method established in this study is standard and the quality standard is perfect

it is suitable for evaluating the quality of standard decoction of Scutellariae Radix.

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Related Institution

Institute of Traditional Chinese Medicine (TCM),Tianjin University of TCM

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