Objective: On evaluate the effectiveness and safety of compound Xiaoyao oral

compound Dihuang oral in the treatment of female precocious puberty patients. Method: The 140 girls who were were diagnosed with hyperactivity of liver-fire and Yin deficiency and Huo exuberance treated at out-patient of our hospital from Sep. 2013 to Aug. 2015.Hyperactivity of liver-fire group were randomly assigned to two groups

the control group was given to Xiaoyaowan

the experimental group was given to compound Xiaoyao oral which was our hospital self-made traditional Chinese medicine. Yin deficiency and Huo exuberance were also randomly assigned to two groups

the control group was given to Zhibai Dihuang Wan

the experimental group was given to compound Dihuang oral. After 3 months treated

all patients were observed the breast changes

uteruses

ovarians volume change and the level of luteinising hormone(LH)

follicle-stimulating hormone(FSH)

estradiol(E2)

sex hormone binding globulin(SHBG)to evaluate its efficacy. At the end day

recording side effect of drug events; blood routine

liver function

renal function to evaluate its safety. Result: The treatment group was better than control group

the breast diameter and the reduction of uterine and ovary volume were changed significantly(P<0.05). In both of two groups the incidence of adverse reactions and no side effect of drug events were found. Conclusion: The compound Xiaoyao oral

compound Dihuang oral treatment of idiopathic true precocious puberty were significant clinical effect and safety reliable.