Correlation Analysis Between Mineral Elements and Active Ingredients in Bupleuri Radix

XUE Wen-feng; LIU Chang-li; ZHANG Shu-hua; ZHAO Xiang-yan; QI Wen-tao

doi:10.13422/j.cnki.syfjx.2017080045

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Correlation Analysis Between Mineral Elements and Active Ingredients in Bupleuri Radix

更新时间：2024-01-04

- Correlation Analysis Between Mineral Elements and Active Ingredients in Bupleuri Radix
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 8, Pages: 45-49(2017)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.2017080045
  CLC： R284
- Published：2017
- 稿件说明：
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XUE Wen-feng, LIU Chang-li, ZHANG Shu-hua, et al. Correlation Analysis Between Mineral Elements and Active Ingredients in Bupleuri Radix[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(8): 45-49.
DOI：

XUE Wen-feng, LIU Chang-li, ZHANG Shu-hua, et al. Correlation Analysis Between Mineral Elements and Active Ingredients in Bupleuri Radix[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(8): 45-49. DOI： 10.13422/j.cnki.syfjx.2017080045.

摘要

目的：通过分析柴胡药材中的矿质元素与有效成分之间的关系，探究其对柴胡药材质量的影响，为提高栽培种柴胡的药材质量提供参考。方法：采用微波消解法消解，采用电感耦合等离子体原子发射光谱法（ICP-AES）测定24批样品中Fe，Mg等16种矿质元素的含量，根据《中国药典》2015年版标准，利用HPLC测定指标成分柴胡皂苷a，d的含量，流动相为水（A）-乙腈（B）梯度洗脱（0~5 min，35%~40% B；5~15 min，40%~45% B；15~25 min，45%~55% B；25~30 min，55%~90% B；30~45 min，90%~35% B），流速1.0 mL·min-1，进样量20 μL，柱温25℃，检测波长210 nm。利用SPSS 17.0软件进行双变量相关方法分析24批样品中矿质元素与有效成分之间的相互关系。结果：不同柴胡样品中矿质元素和有效成分含量都有较大差异，有效成分柴胡皂苷a，d的含量与Cu元素相关系数分别为0.349和0.425，呈显著正相关，与Na元素的相关系数分别为-0.517和-0.420，呈显著负相关。结论：柴胡药材中有效成分柴胡皂苷a，d含量与Cu和Na等矿质元素之间的存在一定关系，建议通过外源施入矿质元素的栽培措施来调控柴胡皂苷a，d在柴胡根中合成，为栽培种柴胡质量的提高提供实验依据。

Abstract

Objective: By analyzing the relationship between mineral elements and effective components in Bupleuri Radix to explore the influence of this relationship on quality of Bupleuri Radix. Method: Samples were digested by microwave digestion method

ICP-AES was employed to determine contents of 16 kinds of mineral elements in 24 batches of samples

then according to standards in the 2015 edition of Chinese Pharmacopoeia

HPLC was adopted to determine contents of saikosaponin a and d with mobile phase of acetonitrile-water for gradient elution and detection wavelength of 210 nm.Relationship between mineral elements and effective components in Bupleuri Radix was analyzed by double variable correlation method with SPSS 17.0 software. Result: Contents of different mineral element and active ingredient in Bupleuri Radix had significant differences.Saikosaponin a and d were significantly positive correlation with Cu element

their correlation coefficients were 0.349 and 0.425;and they had significant negative correlation with Na element

correlation coefficients were -0.517 and -0.420. Conclusion: Mineral elements and contents of effective components in Bupleuri Radix with different growing conditions have a certain difference.It is suggested that saikosaponin a and d can be synthesized in roots of Bupleuri Radix by exogenous application of mineral elements.

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