Objective: To observe the clinical efficacy of modified Guizhi Fuling Tang for varicocele type infertility caused by kidney deficiency and blood stasis

and investigate its mechanism. Method: The 86 patients with varicocele type infertility were randomly divided into treatment group (46 cases) and control group (40 cases). Patients in treatment group were treated with modified Guizhi Fuling Tang

and patients in control group took aescuven forte. Both groups were treated for 3 months

and the patients were followed up for 3 months after the end of the treatment. The clinical efficacy

changes of sperm quality

spermatic vein diameter

and sex hormone levels after the treatment were compared between two groups

meanwhile the pregnancy results of their spouses were observed. Result: The total effectiveness was 84.78% in treatment

higher than 67.50% in control group (P<0.05). The sperm density and sperm motility were improved after treatment in both groups (P<0.05). After treatment

the spermatic vein diameter was narrowed in both groups (P<0.05)

and there was no statistically significant difference between two groups after treatment (P<0.05). After treatment

follicle stimulating hormone (FSH) level was significantly decreased and testosterone (T) level was significantly increased in both groups (P<0.05)

and the increase of T in treatment group was significantly superior to that in control group (P<0.05); but there was no obvious change in luteinizing hormone (LH) level in both groups after treatment. Conclusion: The modified Guizhi Fuling Tang can improve the semen quality in patients with varicocele type infertility caused by kidney deficiency and blood stasis

narrow varicose vein diameter

adjust the reproductive hormone levels and improve the function of sperm production.