Objective: To evaluate the effects of Quyu Huatan Tongmai granule (QHT) on the heart hemodynamics and myocardial consumption of oxygen in experimental beagle dogs. Method: In this experiment

thoracotomy was performed to observe the effects of QHT Granule on the heart hemodynamics and myocardial consumption of oxygen in experimental beagle dogs. Totally 30 beagle dogs were randomly divided into five groups:the normal group

diltiazem group (5 mg·kg-1)

high-dose

medium-dose and low-dose QHT groups (2.0

1.0

0.5 g·kg-1)

with six in each group. They were given the corresponding drugs through duodenum. Multiple physiological recorders were adopted to measure arterial blood pressure

heart rate

standard Ⅱ ECG

coronary blood flow

resistance in coronary artery

cardiac output

left ventricular pressure

the maximal rate (dp/dtmax) of rise of left ventricular pressure

oxygen contents of the coronary artery and coronary vein(venous sinus)

oxygen utilization

and oxygen consumption index. Result: Compared with control group

high-dose

medium-dose and low-dose QHT could significantly increase coronary artery blood flow and reduce coronary resistance. At 15-60 min after administration

high-dose and medium-dose QHT could increase cardiac output

with statistical differences from pre-administration value and normal group; QHT could improve the function of left ventricular; 60 min later after administration

medium-dose QHT could increase venous oxygen content by about 19% and decrease myocardial oxygen consumption by 21%

with statistical differences from normal group and pre-administration value (P < 0.05

P < 0.01). QHT showed no significant impact on heart rate

arterial blood pressure

left ventricular pressure

maximum rise rate of left ventricular pressure

myocardial oxygen consumption index. Conclusion: QHT can improve the cardiac hemodynamics and myocardial oxygen consumption in anesthetized beagle dogs.