Effect of Bushen Huoxue Decoction on Coagulation Function and Inflammatory Reaction of Patients with Intrauterine Adhesions After Surgery

WU Dan

doi:10.13422/j.cnki.syfjx.2017090174

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Effect of Bushen Huoxue Decoction on Coagulation Function and Inflammatory Reaction of Patients with Intrauterine Adhesions After Surgery

更新时间：2024-01-04

- Effect of Bushen Huoxue Decoction on Coagulation Function and Inflammatory Reaction of Patients with Intrauterine Adhesions After Surgery
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 9, Pages: 174-178(2017)
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- DOI：10.13422/j.cnki.syfjx.2017090174
  CLC： R271.9
- Published：2017
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WU Dan. Effect of Bushen Huoxue Decoction on Coagulation Function and Inflammatory Reaction of Patients with Intrauterine Adhesions After Surgery[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(9): 174-178.
DOI：

WU Dan. Effect of Bushen Huoxue Decoction on Coagulation Function and Inflammatory Reaction of Patients with Intrauterine Adhesions After Surgery[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(9): 174-178. DOI： 10.13422/j.cnki.syfjx.2017090174.

摘要

目的：观察补肾活血中药对宫腔粘连术后患者炎症指标和临床疗效的影响，探讨其作用机制。方法： 123例宫腔粘连术后患者随机分成对照组（61例）和观察组（62例）。对照组给予雌孕激素序贯治疗，观察组在对照组的基础上，加服补肾活血中药汤剂。监测2组患者的肝肾功能指标，测定2组患者治疗前后的血红蛋白水平（HGB），部分凝血活酶时间（APTT），D-二聚体（DD）以及各时间点的血清细胞因子肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）的水平。比较2组患者的临床疗效和3个月宫腔再粘连发生率。结果：两组患者治疗前HGB，DD，IL-6，TNF-α水平无明显差别。与对照组比较，观察组治疗后HGB显著提升，DD显著降低（P<0.01），术后第3，7天IL-6和TNF-α显著降低（P<0.01），且观察组临床疗效明显高于对照组（P<0.05）。观察组3个月再粘连发生率（12.90%）明显低于对照组（27.87%）（P<0.05）。结论：补肾活血中药可能通过改善TCRA术后患者的子宫微循环和抑制炎症反应，从而改善患者的临床症状和防止术后再粘连的发生。

Abstract

Objective: To observe the clinical efficacy of traditional Chinese medicine(TCM) of invigorating kidney and promoting blood circulation on the inflammatory factors of patients with intrauterine adhesion after surgery

and explore its mechanism. Method: The 123 patients were randomly divided into control group (61 cases) and observation group (62 cases). Patients in control group were treated by sequential application of Estrogen-progesterone

and those in observation group were also given Bushen Huoxue decoction for two weeks in addition to the therapy of control group. Renal and liver functions of both groups were monitored. Hemoglobin (HGB)

partial thromboplastin time (APTT)

D-dimer (DD) and serum concentration of tumor necrosis factor-α (TNF-α)

interleukin-6 (IL-6) before and after treatment were measured in two groups. The incidence of adhesion within three months was compared. Result: The level of DD was significantly decreased

and HGB were higher after treatment in observation group than that in control group (P<0.01). The levels of TNF-α and IL-6 were lower at the 3rd

7th day after the operation (P<0.01). The clinical curative effect of observation group was significantly higher than that of control group (P<0.05). The incidence of adhesion within three months of observation group was also lower than control group (12.90% vs 27.87%

P<0.05). Conclusion: Bushen Huoxue decoction may improve clinical efficacy and prevent postoperative adhesion in patients by improving uterine microcirculation and inhibiting inflammatory reaction.

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