Preparation and Evaluation of Quercetin Solid Dispersion by Combining Povidone with Precipitated Calcium Carbonate

HOU Tian-ling; ZHANG Qi; LIU Li-hua; GUO Yi-lin; WANG Bing

doi:10.13422/j.cnki.syfjx.2017100017

您当前的位置：

首页 >

文章列表页 >

Preparation and Evaluation of Quercetin Solid Dispersion by Combining Povidone with Precipitated Calcium Carbonate

更新时间：2024-01-04

- Preparation and Evaluation of Quercetin Solid Dispersion by Combining Povidone with Precipitated Calcium Carbonate
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 10, Pages: 17-21(2017)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2017100017
  CLC： R283.6
- Published：2017
- 稿件说明：
移动端阅览
HOU Tian-ling, ZHANG Qi, LIU Li-hua, et al. Preparation and Evaluation of Quercetin Solid Dispersion by Combining Povidone with Precipitated Calcium Carbonate[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(10): 17-21.
DOI：

HOU Tian-ling, ZHANG Qi, LIU Li-hua, et al. Preparation and Evaluation of Quercetin Solid Dispersion by Combining Povidone with Precipitated Calcium Carbonate[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(10): 17-21. DOI： 10.13422/j.cnki.syfjx.2017100017.

摘要

目的：为提高槲皮素的稳定性及溶出度，以聚乙烯吡咯烷酮（PVP）联用轻质碳酸钙（PCC）为载体制备槲皮素固体分散体。方法：采用溶剂法制备固体分散体，以电子扫描显微镜法、差示扫描量热法对槲皮素固体分散体微观结构、物理特征等进行表征分析，利用小杯法考察槲皮素固体分散体的体外溶出行为，通过稳定性影响因素试验考察其稳定性。结果：固体分散体中槲皮素在载体中以无定形状态分散；在15 min时，槲皮素固体分散体[药质比1：3，PVP-PCC（2：1）]的药物累积释放率>90%；稳定性影响因素试验表明固体分散体中药物不受强光、高湿、高温条件的影响。结论：PVP联用PCC作为混合载体所制备的槲皮素固体分散体具有速释效果，能显著改善槲皮素的溶出行为，且稳定性良好。

Abstract

Objective: In order to improve the stability and solubility of quercetin

quercetin solid dispersion was prepared with the combination of polyvinyl pyrrolidone (PVP) and precipitated calcium carbonate (PCC) as carriers. Method: The quercetin solid dispersion was prepared by solvent evaporation method.The microscopic structure and physicochemical properties of the solid dispersion were analyzed by scanning electron microscopy (SEM) and differential scanning calorimetry (DSC)

in vitro dissolution behavior and stability of the solid dispersion were also investigated by small cup method and stability test

respectively. Result: Quercetin in the solid dispersion was amorphous form in the carriers.The cumulative release rate of quercetin in the solid dispersion [drug-matrix (1:3)

PVP-PCC (2:1)]was >90% at 15 min.The stability of quercetin solid dispersion was not affected by light

high humidity and high temperature. Conclusion: Quercetin solid dispersion

prepared by combining PVP with PCC as a hybrid carrier

has an immediate release effect;and it can significantly increase the dissolution behavior of quercetin with good stability.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Quercetin Attenuates Ferroptosis Against LPS-induced Acute Kidney Injury Rats via Modulating Keap1/Nrf2/ARE Pathway

Effect of Quercetin on Cuproptosis in Rheumatoid Arthritis Rats and Its Mechanism via SLC31A1/FDX1 Pathway

Application of Self-assembled Nano-strategies of Traditional Chinese Medicine in Tumor Therapy： A Review

Investigation of Metabolic Stability of Phase Ⅰ and Ⅱ Sulfation of Lucidin in Liver Microsomes and Liver S9 from Different Species

Quercetin Against Cerebral Ischemia-reperfusion Injury： A Review

Related Author

YANG Haoruo

YU Dajun

ZHANG Yu

YANG Bin

YANG Haoruo

KOU Qiuai

REN Junhua

YUAN Guo

Related Institution

Xiyuan Hospital， China Academy of Chinese Medical Sciences

Tianjin University of Chinese Medicine

Tianjin University of Traditional Chinese Medicine

School of TCM，Capital Medical University

Hospital of Chengdu University of Traditional Chinese Medicine （TCM）

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰