Bioinformatics Analysis on Effect of Lonicerae Japonicae Flos and Forsythiae Fructus on Immune Pathway of H1N1 Influenza A

LI Li; DU Ya-wei; KOU Shuang; ZHAO Jing; LYU Cheng; JIANG Miao; LYU Ai-ping

doi:10.13422/j.cnki.syfjx.2017100201

您当前的位置：

首页 >

文章列表页 >

Bioinformatics Analysis on Effect of Lonicerae Japonicae Flos and Forsythiae Fructus on Immune Pathway of H1N1 Influenza A

更新时间：2024-01-04

- Bioinformatics Analysis on Effect of Lonicerae Japonicae Flos and Forsythiae Fructus on Immune Pathway of H1N1 Influenza A
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 10, Pages: 201-204(2017)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2017100201
  CLC： R285
- Published：2017
- 稿件说明：
移动端阅览
LI Li, DU Ya-wei, KOU Shuang, et al. Bioinformatics Analysis on Effect of Lonicerae Japonicae Flos and Forsythiae Fructus on Immune Pathway of H1N1 Influenza A[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(10): 201-204.
DOI：

LI Li, DU Ya-wei, KOU Shuang, et al. Bioinformatics Analysis on Effect of Lonicerae Japonicae Flos and Forsythiae Fructus on Immune Pathway of H1N1 Influenza A[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(10): 201-204. DOI： 10.13422/j.cnki.syfjx.2017100201.

摘要

目的：基于生物信息学方法分析金银花、连翘对甲型H1N1流感免疫调节通路的影响。方法：在台湾中医药资料库，PubChem及Gene公众网络平台数据库查找金银花、连翘的靶蛋白及甲型H1N1流感相关基因，运用生物信息软件对检索到的数据集进行分析，解读金银花、连翘单用和连用对甲型H1N1流感相关的免疫调节生物通路的影响。结果：金银花相关靶蛋白共16个，连翘相关靶蛋白共8个，甲型H1N1流感相关基因32个；生物信息分析发现金银花和连翘有各自作用的特异性的免疫调节通路；对于巨噬细胞中白介素-12信号的生成通路和白介素-8信号通路，二者作为药对使用后，代表药物靶蛋白与生物通路相联性的-log P大于单独使用金银花或连翘；金属蛋白酶家族（MMPs）参与了多数金银花特异性作用的通路，蛋白激酶C-α（PRKCA）参与了连翘特异作用的通路。结论：对于甲型H1N1流感相关的免疫通路，金银花和连翘有各自的调节特点，作为药对使用对对巨噬细胞中白介素-12信号的生成通路和白介素-8信号通路调节更有优势，MMPs和PRKCA可能是金银花和连翘分别作用于免疫通路的关键蛋白。

Abstract

Objective: To study the effect of Lonicerae Japonicae Flos and Forsythiae Fructus on immune pathway of H1N1 Influenza A based on bioinformatics approach. Method: Target proteins of Lonicerae Japonicae Flos and Forsythiae Fructus

and genes of H1N1 Influenza A were searched in TCM Database @Taiwan

PubChem and Gene online public platform databases. Bioinformatics software was used to analyze the data sets

and explain the effect of Lonicerae Japonicae Flos and Forsythiae Fructus on immune pathway of H1N1 Influenza A. Result: There were 16 target proteins of Lonicerae Japonicae Flos

eight target proteins of Forsythiae Fructus and 32 genes of H1N1 influenza A. According to the bioinformatics analysis

Lonicerae Japonicae Flos and Forsythiae Fructus have their specific immune pathways

respectively. After the production pathway of IL-12 signaling and the pathway IL-8 signaling were treated with the drug pairs

the -log P value representing the correlation between drug target protein and biological pathway was higher than that of single administration of Lonicerae Japonicae Flos or Forsythiae Fructus.Matrix metalloproteinases(MMPs) involved in the most of specific immune pathways of Lonicerae Japonicae Flos

and PRKCA involved in the most of specific immune pathways of Forsythiae Fructus. Conclusion: Lonicerae Japonicae Flos and Forsythiae Fructus have their own characteristics in regulating specific immune pathways related to H1N1 Influenza A. When being used as a drug pair

they have more advantages in regulating the production pathway of IL-12 signaling and the pathway IL-8 signaling. MMPs and PRKCA may be the key proteins of Lonicerae Japonicae Flos and Forsythiae Fructus in regulating immune pathways.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effects of Different Compatibility Proportions of Lonicerae Japonicae Flos and Forsythiae Fructus on Dissolution of Active Ingredients and Pharmacokinetics in Rats

Anti-inflammatory Effect and Mechanism of Active Constituents from Lonicerae Japonicae Flos and Lonicerae Flos： A Review

Herbal Textual Research on Forsythiae Fructus in Famous Classical Formulas

Compatibility Rules of Prescriptions Containing Forsythiae Fructus in Dictionary of Traditional Chinese Medicine Prescriptions and Anti-inflammatory Mechanism： An Exploration Based on Data Mining and Network Pharmacology

Quality Control of Dynamic Volatile Components in Lonicerae Japonicae Flos and Lonicerae Flos

Related Author

LIN Yi-ning

GAO Ru

ZHANG Meng

GAO Yuan

WEI Jingyue

LUO Shiwen

FENG Lingran

LIN Wanjun

Related Institution

Basic Research Center of Integrated Chinese and Western Medicine for Prevention and Treatment of Vascular Diseases，Hunan University of Chinese Medicine

Key Laboratory of Vascular Biology and Translational Medicine，Hunan University of Chinese Medicine

Sate Key Laboratory Breeding Base of Dao-di Herbs，National Resource Center for Chinese Materia Medica，China Academy of Chinese Medical Sciences

Key Laboratory of Chemical Biology and Molecular Engineering，Ministry of Education， Institute of Molecular Science，Shanxi University

Jiangxi University of Chinese Medicine

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰