Analysis of Hemorheology and  Transdermal Permeability of Thermal Moxibustion Emplastrum with Jianchangbang Cyperi Rhizoma in Dysmenorrhea Rats

GUO Hui-ling; LUO Yun-xia; HU Lyu-jiang; ZHAO Xiao-juan; HU Zhi-fang; DONG Neng-feng; HU Qiang

doi:10.13422/j.cnki.syfjx.2017110029

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Analysis of Hemorheology and Transdermal Permeability of Thermal Moxibustion Emplastrum with Jianchangbang Cyperi Rhizoma in Dysmenorrhea Rats

更新时间：2024-01-04

- Analysis of Hemorheology and Transdermal Permeability of Thermal Moxibustion Emplastrum with Jianchangbang Cyperi Rhizoma in Dysmenorrhea Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 11, Pages: 29-33(2017)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.2017110029
  CLC： R285.5
- Published：2017
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GUO Hui-ling, LUO Yun-xia, HU Lyu-jiang, et al. Analysis of Hemorheology and Transdermal Permeability of Thermal Moxibustion Emplastrum with Jianchangbang Cyperi Rhizoma in Dysmenorrhea Rats[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(11): 29-33.
DOI：

GUO Hui-ling, LUO Yun-xia, HU Lyu-jiang, et al. Analysis of Hemorheology and Transdermal Permeability of Thermal Moxibustion Emplastrum with Jianchangbang Cyperi Rhizoma in Dysmenorrhea Rats[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(11): 29-33. DOI： 10.13422/j.cnki.syfjx.2017110029.

摘要

目的：探讨四制香附贴膏灸剂对缩宫素所致痛经模型大鼠血液流变性的影响，并初步探究其体外透皮特性。方法：SD大鼠随机分为空白组、模型组、四制香附贴膏灸剂组（贴膏灸剂组）及四制香附石油醚部位浸膏组（浸膏组）。通过灌胃己烯雌酚增敏，观察腹腔注射缩宫素后30 min内大鼠扭体发生的潜伏期及次数，测试各组大鼠的全血黏度和血浆黏度；采用改良的Franz扩散池，以小鼠离体皮肤为渗透屏障进行体外透皮试验，利用HPLC同时测定α-香附酮和香附烯酮的体外透皮渗透量，分别对四制香附贴膏灸剂组和不加发热辅助材料的四制香附贴膏剂组进行研究。结果：贴膏灸剂组和浸膏组均显著延长大鼠扭体反应发生的潜伏期，显著减少30 min内大鼠扭体发生次数，且贴膏灸剂组优于浸膏组；贴膏灸剂组和浸膏组均可显著降低痛经模型大鼠的全血黏度和血浆黏度，贴膏灸剂组更佳。四制香附贴膏灸剂中香附烯酮和α-香附酮24 h内的渗透速率分别为58.58，45.42 μg·cm-2·h-1，均高于不加发热辅助材料的贴膏剂组，透皮行为符合Higuchi方程。结论：四制香附贴膏灸剂可显著提高四制香附抗痛经有效成分的透皮释药性能，对大鼠痛经模型有良好的镇痛作用，可显著改善痛经大鼠的血液流变性。

Abstract

Objective: To discuss the effect of thermal moxibustion emplastrum with Jianchangbang Cyperi Rhizoma on hemorheology of dysmenorrhea rats caused by oxytocin and to investigate its in vitro transdermal absorption properties. Method: SD rats were randomly divided into 4 groups

such as the blank group

model group

thermal moxibustion emplastrum with Jianchangbang Cyperi Rhizoma group and petroleum ether extract of Jianchangbang Cyperi Rhizoma group.The dysmenorrhea rats model were made by oxytocin and diethylstilbestrol

then were observed the times and incidence of wrings within 30 minutes.The blood viscosity and plasma viscosity of rats in all groups was tested by automatic blood rheometer.The percutaneous permeation of α-cyperone and cyperotundone in the thermal moxibustion emplastrum with Jianchangbang Cyperi Rhizoma was studied by in vitro transdermal delivery experiment with Franz diffusion cells and their contents were determined by HPLC. Result: Thermal moxibustion emplastrum group and petroleum ether extract group could significantly reduce the times and incidence of wrings within 30 minutes

and the thermal moxibustion emplastrum group was better than the petroleum ether-extract group.Compared with the blank group

the model group significantly increased the whole blood viscosity and plasma viscosity

but the thermal moxibustion emplastrum group and the petroleum ether-extract group could significantly reduce them of model rats

also the thermal moxibustion emplastrum was better.The permeation rates of α-cyperone and cyperotundone from the thermal moxibustion emplastrum with Jianchangbang Cyperi Rhizoma were 45.42

58.58 μg·cm-2·h-1

and their transdermal behavior conformed to Higuchi equation. Conclusion: Thermal moxibustion emplastrum with Jianchangbang Cyperi Rhizoma can significantly improve the drug release properties of active ingredients with auxiliary heating materials

it can effectively relieve oxytocin-induced pain in rats and improve hemorheology of dysmenorrhea rats.

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Related Author

HU Lyu-jiang

XU Qian-qian

ZHAO Xiao-juan

GUO Hui-ling

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GUO Hui-ling

DONG Neng-feng

HU Zhi-fang

Related Institution

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Institute of Basic Theory of Chinese Medicine，China Academy of Chinese Medical Sciences

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