Objective: To observe the effect of Zhigancao Tang on heart rate variability and inflammatory factors in patients with cardiac arrhythmia with Qi-Yin deficiency. Method: A total of 90 patients with definite arrhythmia were randomly divided into treatment group (47 cases) and control group (43 cases). The control group received routine Western medicine plus amiodarone tablets

and treatment group was treated with Zhigancao Tang in addition to the therapy of control group. Both groups were treated for 8 weeks

and their arrhythmia efficacy

traditional Chinese medicine (TCM) symptom score and efficacy

heart rate variability (HRV)

interleukin-6 (IL-6)

and high sensitivity C-reactive protein (hs-CRP) indicators were compare. Result: After treatment

the therapeutic effect of arrhythmia in treatment group was better than that in control group (P<0.05). According to the comparison of TCM syndromes between two groups after treatment

the total effective rate in treatment group was higher than that in control group (P<0.05). Compared with before treatment

both groups could improve TCM symptom scores

and the score of improvement in treatment group were better than that in control group (P<0.01). After treatment

HRV in both groups was increased (P<0.05

P<0.01)

while IL-6 and hs-CRP were decreased in both groups (P<0.05

P<0.01)

the improvements of HRV

IL-6 and hs-CRP in treatment group were better than that in control group (P<0.01). Conclusion: Zhigancao Tang can improve the clinical efficacy of arrhythmia

regulate heart rate variability

inhibit inflammatory cytokines

improve clinical symptoms and repair cardiac autonomic neuropathy and inflammatory injury in patients with arrhythmia.