Effect of Modified Treatment of Bazhen Decoction to Cancer-related Fatigue Immune Function After Colorectal Surgery

ZHANG Jian-jun; ZHANG Yong-qiang; ZHOU Fang; HU Jun-hong

doi:10.13422/j.cnki.syfjx.2017110196

您当前的位置：

首页 >

文章列表页 >

Effect of Modified Treatment of Bazhen Decoction to Cancer-related Fatigue Immune Function After Colorectal Surgery

更新时间：2024-01-04

- Effect of Modified Treatment of Bazhen Decoction to Cancer-related Fatigue Immune Function After Colorectal Surgery
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 11, Pages: 196-201(2017)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2017110196
  CLC： R273
- Published：2017
- 稿件说明：
移动端阅览
ZHANG Jian-jun, ZHANG Yong-qiang, ZHOU Fang, et al. Effect of Modified Treatment of Bazhen Decoction to Cancer-related Fatigue Immune Function After Colorectal Surgery[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(11): 196-201.
DOI：

ZHANG Jian-jun, ZHANG Yong-qiang, ZHOU Fang, et al. Effect of Modified Treatment of Bazhen Decoction to Cancer-related Fatigue Immune Function After Colorectal Surgery[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(11): 196-201. DOI： 10.13422/j.cnki.syfjx.2017110196.

摘要

目的：观察八珍汤加味对大肠癌术后患者癌因性疲乏（CRF）气血两虚证患者疲乏状态、生活质量和免疫功能的影响。方法：160例患者按完全计算机软件平衡分组法，分为对照组和观察组各80例。两组患者均给予止痛、止吐、营养支持、适当的有氧运动、免疫调节、改善睡眠、心理护理等综合对症处理。对照组口服补中益气合剂，10 mL/次，3次/d。观察组内服八珍汤加味，2次/d，1剂/d。两组疗程均为3个月。进行治疗前后Piper疲乏修订量表（PFS-R），气血两虚证辨证评分和癌症患者生命质量测定量表（EORTC QLQ-C30）评分，检测治疗前后T淋巴细胞亚群（CD3+，CD4+，CD8+，CD4+/CD8+），自然杀伤细胞（NK），肿瘤坏死因子-α（TNF-α），白细胞介素-1β（IL-1β）和干扰素-γ（IFN-γ）的水平。结果：治疗后观察组PFS-R评分和气血两虚证辨证评分均低于对照组（P<0.01）；经Ridit分析，治疗后观察组疲乏程度轻于对照组（P<0.01）；观察组治疗后QLQ-BR30量表躯体功能、角色功能、情绪功能、认知功能和社会功能和整体生活质量评分均高于对照组（P<0.01），疲劳、恶心呕吐、睡眠困难、食欲下降、便秘、腹泻等症状评分均低于对照组（P<0.01）；观察组CD3+，CD4+，CD4+/CD8+和NK水平均高于对照组，CD8+低于对照组（P<0.01）；观察组炎症因子TNF-α和IL-1β水平均低于对照组，IFN-γ水平高于对照组（P<0.01）。结论：八珍汤加味治疗大肠癌术后CRF患者，可调节免疫炎症因子，提高机体的免疫功能，有效的改善CRF症状，提高患者生活质量。

Abstract

Objective: To observe the effects of Bazhen decoction modified fatigue state

quality of life and immune function in patients with cancer-related fatigue (CRF) and Qi and blood deficiency after colorectal cancer surgery. Method: One hundred and sixty patients were divided into control group (80 cases) and observation group (80 cases) by complete computer software balanced grouping method. The patients in both groups received comprehensive symptomatic treatment such as relieving pain

antiemetic

nutritional support

appropriate aerobic exercise

immunomodulatory

improving sleeping

psychological adjustment and nursing. Patients in control group received Buzhong Yiqi mixture

10 mL/time

3 times/day. Patients in observation group received Bazhen decoction modified

2 times/day

1 dose/day. The course of treatment was 3 months in both groups. Before and after treatment

Piper fatigue revision scale (PFS-R)

Qi and blood deficiency and quality of life measurement for cancer patients (EORTC QLQ-C30) scale were graded

and levels of T lymphocyte subsets (CD3+

CD4+

CD8+

CD4+/CD8+)

natural killer cells (NK)

tumor necrosis factor-α (TNF-α)

interleukin-1β (IL-1β) and interferon-γ (IFN-γ) were detected. Result: After treatment

scores of PFS-R and Qi and blood deficiency in observation group were lower than those in control group (P<0.01). Ridit analysis showed that

degree of fatigue in observation group was lighter than that in control after treatment (P<0.01).Scores of somatic function

role function

emotional function

cognitive function

social function and overall quality of life were higher than those in control (P<0.01). And scores of fatigue

nausea and vomiting

sleep difficulties

loss of appetite

constipation and diarrhea were lower than those in control group (P<0.01). Levels of CD3+

CD4+

CD4+/CD8+

NK and IFN-γ in observation group were higher than those in control group (P<0.01). While the levels of TNF-α and IL-1β were lower than those in control group (P<0.01). Conclusion: Bazhen decoction modified can regulate inflammatory factors

improve immune function

and ameliorate symptoms caused by CRF and improve their quality of life.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of Dingkundan in Adjuvant Treatment of Patients with Radiotherapy and Chemotherapy After Endometrial Carcinoma Operation

Effect of Modified Qingzao Jiufei Tang on Quality of Life and Survival Period of Patients with Non-small Cell Lung Cancer

Effect of Wenyang Huashi Prescription on Inflammatory Factors and Immune Function of Patients After Allergic Fungal Rhinosinusitis

Clinical Effect of Wandaitang on Endometrial Carcinoma After Operation

Clinical Efficacy of Jinshui Liujunjian Combined with Breathing Exercises in Treatment of Pneumoconiosis in Stable Phrase with Syndrome of Deficiency of Lung, Spleen and Kidney

Related Author

Si-ying PAN

Dan ZHANG

Xiu-fen WANG

Li TIAN

Yan-jie SUN

Yuan-lin CHEN

Jun-bao LIU

GU Fang-hong

Related Institution

Zhengzhou Shuqing Medical College

Henan People's Hospital

The Third Affiliated Hospital of Henan University of Chinese Medicine

Qingpu Branch, Zhongshan Hospital Affiliated to Fudan University

Henan Province Hospital of Traditional Chinese Medicine (The Second Affiliated Hospital of Henan University of Chinese Medicine)

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰