Objective: To observe the clinical efficacy of Guanxin granules on stable angina pectoris with heart-blood stasis syndrome and investigate its effect on platelet activation. Method: One hundred and fifty-four patients were randomly divided into control group (77 cases) and observation group (77 cases) by random number table. In observation group

the patients took aspirin enteric-coated tablets 0.1 g

1 time/day

trimetazidine dihydrochloride tablets

20 mg

3 times/day. In addition

the patients with high blood fat

high blood pressure

or diabetes got symptomatic treatment (secondary prevention of coronary heart disease). Based on the treatment of control group

patients in observation group got Guanxin granules

1 dose/day in both morning and evening. The treatment course was 20 weeks in both groups. Attack times of angina pectoris

duration of attack

degree of pain

inducing factors and the relationship with physical activity were recorded. Before and after treatment

changes of electrocardiogram and blood lipid were measured. Scores of seattle angina scale (SAQ) and heart-blood stasis syndrome were graded; levels of high sensitive C reactive protein (hs-CRP)

homocysteine (HCY)

serum cystatin-C (Cys-C)

platelet membrane glycoprotein CD63 and CD42 b

and matrix metalloproteinases-9 (MMP-9) were detected. Result: The total effective rate for the disease was 92.21% in observation group

higher than 77.92% in control group (P<0.05). The total effective rate for traditional Chinese medicine syndrome was 93.51%

higher than 72.73% in control group (P<0.01). After treatment

attack times of angina pectoris in observation group were less than those in control group. The duration time was less than that in control group

and consumption of glyceryl trinitrate was also less than that in control group (P<0.01). Leads number of ST segment down shift

leads number of T wave lowering

and leads number of T wave inverting were all less than those in control group (P<0.01). After treatment

TG abnormal rate in observation group was 10.39%

lower than 22.08% in control group (P<0.05).TC abnormal rate was 9.09

lower than 25.97% in control group (P<0.01). HDL-C abnormal rate was 12.99%

lower than 28.57% in control group (P<0.05).And SAQ scores were higher than those in control group

while heart-blood stasis syndrome score was lower than that in control group (P<0.01). In addition

the levels of hs-CRP

HCY

CysC

CD63 and MMP-9 were lower than those in control group

while level of CD42 b was higher than that in control group after treatment (P<0.01). Conclusion: Guanxin granules can reduce the degree of angina pectoris attacks

regulate lipid metabolism

inhibit the inflammatory response and platelet activation

thereby improving myocardial ischemia

and increasing clinical efficacy in the treatment of stable angina pectoris with heart-blood stasis syndrome