Fuzheng Jianer Paste Treatment on Recurrent Upper Respiratory Tract Infection in Children at Non-acute Period

YU Yu; LI Ke-yu

doi:10.13422/j.cnki.syfjx.2017120188

您当前的位置：

首页 >

文章列表页 >

Fuzheng Jianer Paste Treatment on Recurrent Upper Respiratory Tract Infection in Children at Non-acute Period

更新时间：2024-01-04

- Fuzheng Jianer Paste Treatment on Recurrent Upper Respiratory Tract Infection in Children at Non-acute Period
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 12, Pages: 188-193(2017)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2017120188
  CLC： R272
- Published：2017
- 稿件说明：
移动端阅览
YU Yu, LI Ke-yu. Fuzheng Jianer Paste Treatment on Recurrent Upper Respiratory Tract Infection in Children at Non-acute Period[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(12): 188-193.
DOI：

YU Yu, LI Ke-yu. Fuzheng Jianer Paste Treatment on Recurrent Upper Respiratory Tract Infection in Children at Non-acute Period[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(12): 188-193. DOI： 10.13422/j.cnki.syfjx.2017120188.

摘要

目的：观察扶正健儿膏方对小儿反复呼吸道感染（RRTI）非急性期患者病情的控制作用及对T淋巴细胞亚群、免疫球蛋白和Th1/Th2细胞因子的影响。方法：将160例RRTI非急性期患儿，采用SAS软件生成的数字表法，按就诊先后顺序随机分为对照组和观察组。对照组采用匹多莫德口服溶液，400 mg/次，1次/d；葡萄糖酸锌口服溶液，3~6岁，5 mL/次，2次/d；7~12岁，7.5 mL/次，2次/d；适量补充维生素C和A。观察组采用扶正健儿膏方，3~6岁，5 mL/次，温水冲服，晨起空腹，3次/d；7~12岁，10 mL/次，2次/d。两组疗程均连续服用24周，疗程结束均进行24周的随访。记录48周内呼吸道感染发作次数，每次发作的持续时间，每次发病病种；检测治疗前后血清免疫球蛋白G（IgG），免疫球蛋白A（IgA），免疫球蛋白M（IgM）和T淋巴细胞亚群（CD3+，CD4+，CD8+，CD4+/CD8+）水平，检测治疗前后白细胞介素-2（IL-2），干扰素-γ（FN-γ），白细胞介素-4（IL-4），白细胞介素-5（IL-5）水平。结果：观察组临床疗效痊愈率为52.7%高于对照组的32.88%（χ2=5.898，P<0.05）；观察组中医证候疗效总有效率为94.59%，对照组为78.08%，观察组高于对照组（χ2=8.524，P<0.01）；在48周的观察期内，观察组平均发作次数，即反复上呼吸道感染、反复气管支气管炎和反复肺炎的发作次数均少于对照组，平均发病病程也短于对照组（P<0.01）；治疗后观察组IgG，IgA，IgM水平高于对照组（P<0.01）；治疗后观察组CD3+，CD4+和CD4+/CD8+均高于对照组，CD8+低于对照组（P<0.01）；治疗后观察组血清IL-2和IFN-γ水平均高于对照组，IL-4和IL-5水平均低于对照组（P<0.01）。结论：扶正健儿膏方治疗反复呼吸道感染患儿，能提高患者的免疫功能，调节Th1/Th2平衡，增加患儿机体免疫能力，从而减少呼吸道感染发生频率，缩短发作病程，提高临床疗效。

Abstract

Objective: To observe the effect of Fuzheng Jianer paste on non acute phase of recurrent upper respiratory tract infection (RRTI) in children

and investigate its effect on levels of T lymphocyte subsets

immunoglobulin and Th1/Th2 cell factor. Method: One hundred and sixty patients with RRTI at non acute phase were randomly divided into control group and observation group by random number table. Patients in control group received pidotimod oral solution

400 mg/time

1 time/day. Zinc gluconate oral solution

5 mL/time

2 times/day for 3-6 years old

and 7.5 mL/time

2 times/day for 7-12 years old; and vitamin A and C were appropriately supplemented. In observation group

the patients received Fuzheng Jianer paste

5 mL/time

3 times/day for morning fasting for 3-6 years old

10 mL/time for 7-12 years old

2 times/day. The course of treatment was 24 weeks for both groups. An follow-up after the treatment course was conducted for 24 weeks. Attack times of respiratory tract infection

duration time and disease type were recorded during the 48 weeks. Levels of serum immunoglobulin (IgA

IgG and IgM)

T lymphocyte subsets (CD3+

CD4+

CD8+

CD4+/CD8+)

interleukin-2 (IL-2)

interferon-γ (IFN-γ)

interleukin-4 (IL-4) and interleukin-5 (IL-5) were detected. Result: Clinical curative effect was 52.7% in observation group

higher than 32.88% in control group (χ2=5.898

P<0.05). Total effective rate of traditional Chinese medicine (TCM) symptoms was 94.59% in observation group

higher than 78.08% in control group (χ2=8.524

P<0.01). During 48 weeks

the average numbers of attacks (recurrent upper respiratory tract infection

bronchitis

pneumonia) in observation group was less than those in control group

and the average course of disease was also shorter than that in control group (P<0.01). The levels of IgG

IgA and IgM as well as CD3+

CD4+ and CD4+/CD8+ and IL-2 and IFN-γ in observation group were higher than those in control group after treatment (P<0.01)

and the levels of CD8+

IL-4 and IL-5 were lower than those in control group (P<0.01). Conclusion: Fuzheng Jianer paste can improve immunity

regulate balance of Th1/Th2

so it can reduce occurrence frequency of respiratory tract infection

shorten attack course

improve cure RRTI rate in the treatment of RRTI with high safety and reliability.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Clinical Efficacy of Modified Shenling Baizhusan on Stroke-associated Pneumonia with Lung-Qi Deficiency Syndrome

Mechanism of Shaoyaotang in Modulating MDSCs-related Immunosuppressive Microenvironment in Prevention and Treatment of Colitis-associated Carcinogenesis

Tongxie Yaofang Regulates T Lymphocyte Subsets to Improve Immune Microenvironment of Colorectal Cancer Under Chronic Stress

Clinical Efficacy of Qinghao Fuzheng Jiedu Decoction in Treatment of Systemic Lupus Erythematous

Study on Regulatory Action of Addition and Subtraction of Therapy of Zidiantang to Mmune Inflammatory Factors of Children with Purpura Nephritis

Related Author

De-xu LI

Xin-wen ZHANG

LI Weidong

CHEN Xue

WANG Chenglei

YANG Bingwei

ZHAI Haoyu

WU Ying

Related Institution

Affiliated Hospital of Hebei University

Guang'anmen Hospital， China Academy of Chinese Medical Sciences

Shaanxi University of Chinese Medicine

Traditional Chinese Medicine （TCM） Regulating Metabolic Diseases Key Laboratory of Sichuan Province， Hospital of Chengdu University of TCM

Cancer Institute， Chengdu University of TCM

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰