Effect of Glass Transition Temperature of Traditional Chinese Medicine Extract Powder and Excipients Blends on Dry Granulation of Ju'anshen Preparation
|更新时间:2024-01-04
|
Effect of Glass Transition Temperature of Traditional Chinese Medicine Extract Powder and Excipients Blends on Dry Granulation of Ju'anshen Preparation
Chinese Journal of Experimental Traditional Medical FormulaeVol. 23, Issue 13, Pages: 13-17(2017)
LIU Qiao-li, LUO Xiao-jian, LIANG Hong-bo, et al. Effect of Glass Transition Temperature of Traditional Chinese Medicine Extract Powder and Excipients Blends on Dry Granulation of Ju'anshen Preparation[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(13): 13-17.
DOI:
LIU Qiao-li, LUO Xiao-jian, LIANG Hong-bo, et al. Effect of Glass Transition Temperature of Traditional Chinese Medicine Extract Powder and Excipients Blends on Dry Granulation of Ju'anshen Preparation[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(13): 13-17. DOI: 10.13422/j.cnki.syfjx.2017130013.
Effect of Glass Transition Temperature of Traditional Chinese Medicine Extract Powder and Excipients Blends on Dry Granulation of Ju'anshen Preparation
Objective: To investigate effect of glass transition temperature (Tg) of material on granulating effect based on the theory of glass transition. Method: Taking Ju'anshen preparation extract powder as the model drug
Tg of the mixture of extract powder and excipients was determined
the effect of two mixing ways (direct mixing and co-solvent spray drying) on dry granulation was compared.The mechanism of sticking wall in spray drying and sticking wheel in dry granulation was analyzed by particle size and scanning electron microscopy. Result: When Tg values of spray powder was 58.8 ℃ and 68.5 ℃
which were higher than the roller temperature (42 ℃)
it would not cause sticking wheel in the granulation process;while the Tg values of straight blend were less than 42 ℃
it would cause sticking wheel.Maltodextrin was chosen as the excipients of Ju'anshen granules with ratio of extract powder-maltodextrin (1:1). Conclusion: Tg values can be used as a evaluation index for dry granulation
which is a guidance for the preparation of traditional Chinese medicine granules.
Cause Analysis and Solution Strategy of Poor Solubility of Dioscoreae Rhizoma Formula Granules
Spray Drying in Research of Traditional Chinese Medicine Powders: A Review
Establishment of Feedforward Control Model for Dry Granulation of Polysaccharide Components Based on Quality by Design
Research Progress of Granulation Technology for Taste Masking of Pharmaceutical Preparation
Study on Dry Granulation Technique for Shuanghuanglian Effervescent Tablets
Related Author
LIAO Wei
ZHANG Dingkun
GUO Zhiping
RUAN Shifa
GE Chunli
LIAO Jiabao
HAN Li
Shengyun DAI
Related Institution
School of Pharmacy,State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine
Sichuan Houde Pharmaceutical Technology Co. Ltd.
China Resources Sanjiu Modern Chinese Medicine Pharmaceutical Co. Ltd.
National Institutes for Food and Drug Control
School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing Key Laboratory for Production Process Control and Quality Evaluation of Traditional Chinese Medicine, Engineering Research Center of Key Technologies for Chinese Medicine Production and New Drug Development,Ministry of Education