LIN Jun-zhi, ZHANG Ding-kun, PEI Jin, et al. Investigation of Quality Markers Between Aconiti Lateralis Radix Praeparata in Jiangyou and Anxian Based on Plant Metabolomics[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(13): 35-40.
DOI:
LIN Jun-zhi, ZHANG Ding-kun, PEI Jin, et al. Investigation of Quality Markers Between Aconiti Lateralis Radix Praeparata in Jiangyou and Anxian Based on Plant Metabolomics[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(13): 35-40. DOI: 10.13422/j.cnki.syfjx.2017130035.
Investigation of Quality Markers Between Aconiti Lateralis Radix Praeparata in Jiangyou and Anxian Based on Plant Metabolomics
Objective: To analyze difference of chemical ingredients between Aconiti Lateralis Radix Praeparata in Jiangyou and Anxian by UPLC-Q-TOF/MS. Method: UPLC-Q-TOF/MS was carried out to acquire chemical constituents informations from Aconiti Lateralis Radix Praeparata samples in Jiangyou and Anxian.High precise mass data were filtered and standardized processed by MassHunter B. 05.00 software and MetaboAnalyst 3.0 software
then these data were processed by multivariate statistical analysis techniques by SIMCA-P 13.0 software to discover and identify the constituents with significant difference. Result: Sixteen chemical markers with significant difference were screened by partial least squares discriminant analysis (PLS-DA).During which
the contents of mesaconitine
aconitine
chasmanine
talatisamine
benzoylmesaconitine
benzoylhypaconitine
dehydrated benzoylmesaconitine and mesaconine were higher in Aconiti Lateralis Radix Praeparata from Anxian
while the contents of neoline
fuziline
hypaconitine
talatidine
carmichaeline
fuzitine and songorine were much higher in Aconiti Lateralis Radix Praeparata from Jiangyou.The formation of this difference is related to the difference in cultivation conditions between these two places. Conclusion: Comprehensive analysis for the toxicity and activity of chemical markers in Aconiti Lateralis Radix Praeparata from these two places
the toxicity
analgesic and anti-inflammatory activity of samples in Anxian are much stronger
while the cardiac activity of samples in Jiangyou may be stronger.
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