Objective: To observe the clinical efficacy of Yiqi Huoxue decoction on patients with diabetic kidney disease with Qi and Yin deficiency and blood stasis syndrome

in order to explore its mechanism from the perspective of micro-inflammatory. Method: A randomized

parallel-controlled clinical trial was conducted. A total of 70 patients of diabetic nephropathy with Qi and Yin deficiency and blood stasis syndrome were randomly divided into control group (34 cases) and treatment group (36 cases) according to the random number table. The two groups of patients were given basic treatment (including control diet

blood glucose

blood pressure

lipids) and traditional Chinese medicine. The treatment group was given Yiqi Huoxue decoction for 12 weeks

while the control group was given DM120 formula. Before and after treatment

the patients' serum creatinine

urea nitrogen

serum albumin

urinary albumin/creatinine ratio

serum C-reactive protein (CRP) and interleukin-8 (IL-8) were detected. Result: In treatment group

patients' serum creatinine

urinary albumin/creatinine ratio

serum CRP and IL-8 decreased (P<0.05

P<0.01); serum albumin and glomerular filtration rate obviously increased (P<0.01) after 12 weeks. At the same time

treatment group was superior to control group in decrease of the urinary albumin /creatinine ratio

increase of serum albumin and inhibition of serum CRP and IL-8 (P<0.05). Conclusion: Yiqi Huoxue decoction can protect the renal function of diabetic kidney disease(DKD) patients

decrease proteinuria

and delay the progress of DKD in the early stage. And its mechanism may be related to inhibition of the levels of inflammatory cytokines

such as CRP and IL-8

which can improve the micro inflammatory state of DKD.