Objective: To investigate the effect of Tongqiao Huoxuetang on serum neuro-biology markers

cerebrospinal fluid p73

p38 factor expressions and cognitive ability of patients of posttraumatic water-stasis stagnation type hydrocephalus. Method: A total of 74 cases of posttraumatic hydrocephalus treated at our hospital were selected and randomly divided into 2 groups. The 37 cases in control group were treated with conventional therapy

while the 37 cases in experiment group were treated with Tongqiao Huoxuetang in addition of the conventional therapy of control group. The levels of serum myelin basic protein (MBP)

Protein S100β

Neuron-Specificenolase (NSE)

p73 factor

p38 factors

Mini-mental State Examinatlon (MMSE)

and Glasgow coma scale (GCS) were observed and recorded. Meanwhile

clinical efficacy and adverse reactions were compared. Result: After 2 weeks of treatment

the total efficiency of experiment group was higher than that of control group(P<0.05). Compared with before treatment

levels of serum MBP

S-100β and NSE in both of the 2 groups decreased. Compared with control group

the levels of serum MBP

S-100β and NSE in experiment group were lower (P<0.05). Compared with before treatment

levels of p38

p73 factor in cerebrospinal fluid increased. Compared with control group

the levels of p38

p73 factor in cerebrospinal fluid in the experiment group were higher (P<0.05). Compared with before treatment

the levels of serum MBP and NSE in both of the 2 groups increased. Compared with the control group

the levels of serum MBP and NSE in the experiment group were higher (P<0.05). Conclusion: Tongqiao Huoxuetang can effectively alleviate clinical symptoms of the patients

which may be correlated with decrease in serum MBP

S-100β

NSE of patients of posttraumatic water-stasis stagnation type hydrocephalus

and increase in CSF p73 factor and p38 factor.