LAI Yan-ni, YAN Yi-wen, XU Pei-ping. Pharmacological Mechanism of Curcumae Rhizoma Based on System Pharmacology[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(14): 177-182.
DOI:
LAI Yan-ni, YAN Yi-wen, XU Pei-ping. Pharmacological Mechanism of Curcumae Rhizoma Based on System Pharmacology[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(14): 177-182. DOI: 10.13422/j.cnki.syfjx.2017140177.
Pharmacological Mechanism of Curcumae Rhizoma Based on System Pharmacology
Objective: To explore the pharmacological mechanism of Curcumae Rhizoma through a series of system pharmacology methods. Method: Active ingredients of Curcumae Rhizoma were obtained through traditional Chinese Medicine Systems Pharma cology(TCMSP) database. The target proteins of Curcumae Rhizoma were obtained by PharmMapper Server
the gene name of the targets were obtained by UniProt database
and the main diseases related to Curcumae Rhizoma were obtained by the database of CTD. Then
the target proteins interaction network of Curcumae Rhizoma was built using software Cytoscape. Next
gene ontology (GO) analysis on protein groups and enrichment analysis on action pathways were performed by DAVID tool. Result: Text mining results showed that relevant diseases of Curcumae Rhizoma included neoplastic diseases
neurological diseases and metabolic diseases. GO analysis indicated that Curcumae Rhizoma played a biological role mainly through steroid hormone-mediated signaling pathways
RNA polymerase Ⅱ promoter transcription
negative regulation of process
peptidyl tyrosine phosphorylation
protein autophosphorylation
retinoic acid receptor signaling pathways and positive regulation of transcription from RNA polymerase Ⅱ promoter. The signaling pathway enrichment results showed that main action proteins of Curcumae Rhizoma were related to the pathways of cancer
PPAR signal pathway
proteoglycan in cancer
non-small cell carcinoma and PI3K-Akt signaling pathway. Conclusion: Curcumae Rhizoma may exert its biological functions primarily by regulating multiple pathways
such as cancer pathway
PPARP signaling pathway
PI3K-Akt signaling pathway. The pharmacological action of a drug can be rapidly and comprehensively analyzed through system pharmacology.
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