Mechanism and Effect of Xiaoer Feike Granule on Post-infection Cough

MA Wen-jian; LU Yu-fen; LIU Yong-xin; LI Ke

doi:10.13422/j.cnki.syfjx.2017140204

您当前的位置：

首页 >

文章列表页 >

Mechanism and Effect of Xiaoer Feike Granule on Post-infection Cough

更新时间：2024-01-04

- Mechanism and Effect of Xiaoer Feike Granule on Post-infection Cough
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 14, Pages: 204-209(2017)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2017140204
  CLC： R725.6
- Published：2017
- 稿件说明：
移动端阅览
MA Wen-jian, LU Yu-fen, LIU Yong-xin, et al. Mechanism and Effect of Xiaoer Feike Granule on Post-infection Cough[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(14): 204-209.
DOI：

MA Wen-jian, LU Yu-fen, LIU Yong-xin, et al. Mechanism and Effect of Xiaoer Feike Granule on Post-infection Cough[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(14): 204-209. DOI： 10.13422/j.cnki.syfjx.2017140204.

摘要

目的：观察小儿肺咳颗粒治疗儿童感染后咳嗽的临床疗效及对血清降钙素原基因相关肽（CGRP），半胱氨酰白三烯（CysLTs），肿瘤坏死因子-α（TNF-α），白细胞介素-8（IL-8）水平的影响。方法：170例患儿采用随机数字表法，按就诊先后分为对照组和观察组各85例。对照组采用孟鲁司特钠咀嚼片，< 6岁者，4 mg·d-1，6～12岁剂量为5 mg·d-1，1次/d。严重咳嗽者加布地奈德气雾剂，0.5 mg/次，2次/d，雾化吸入。观察组在对照组治疗的基础加用小儿肺咳颗粒，< 4岁，3 g/次，4～6岁，6 g/次，6～12岁 9 g/次，3次/d。两组疗程均为2周。进行咳嗽程度评分，包括日间和夜间咳嗽情况，及咳嗽视觉模拟评分（VAS）；对日间咳嗽、夜间咳嗽、痰黏稠、咯痰清稀、咽痒、神疲、纳呆、肢倦、声重等中医证候进行治疗前后评分；咳嗽生活质量采用莱塞斯特咳嗽问卷（LCQ），治疗前后各评价1次；检测治疗前后血清CGRP，CysLTs，TNF-α和IL-8水平；并进行安全性评价。结果：对照组咳嗽消失率39.42%，观察组咳嗽消失率62.5%，观察组咳嗽消失率高于对照组（χ2=8.601，P<0.01），观察组平均咳嗽消失时间短于对照组（P<0.01）；观察组中医疗效总有效率为97.5%，高于对照组的83.54%（χ2=9.061，P<0.01）；治疗后观察组日间咳嗽、夜间咳嗽和咳嗽VAS评分均低于对照组（P<0.01）；治疗后观察组LCQ量表各维度（生理、心理、社会）和总分均高于对照组（P<0.01）；治疗后观察组患儿血清CGRP，CysLTs，TNF-α和IL-8水平均低于对照组（P<0.01）。治疗时未发现与小儿肺咳颗粒相关不良反应。结论：小儿肺咳颗粒治疗儿童感染后咳嗽能有效的减轻咳嗽程度，缩短咳嗽病程，提高咳嗽的消失率和中医临床疗效，并能显著提高患者生活质量，其作用机制可能与下调CGRP，CysLTs，TNF-α和IL-8水平，减轻气道炎症反应、降低气道高反应和咳嗽反射敏感性有关。

Abstract

Objective: To observe the clinical effect of Xiaoer Feike granule on cough after infection and its impact on levels of serum calcitonin gene related peptide (CGRP)

cysteinyl leukotrienes (CysLTs)

tumor necrosis factor-α (TNF-α) and interleukin-8 (IL-8). Method: One hundred and seventy patients were divided into control group (85 cases) and observation group (85 cases) by random number table. In control group

patients got montelukast sodium chewable tablets

4 mg/day for those aged below 6 years old

5 mg/day for those aged between 6 and 12 years old

1 time/day. Patients with severe cough got budesonide aerosol

0.5 mg/time

2 time/day. In addition to the therapy of control group

patients in observation were also administered with Xiaoer Feike granule

3 g/time for those aged below 4 years old

and 6 g/time for those aged between 4 and 6 years old

9 g/time

3 time/day. The course of treatment for both of the groups was 2 weeks. Cough degree for day and night and visual analogy score (VAS) were graded. And scores of traditional Chinese medicine (TCM) syndrome

such as daytime cough

nocturnal cough

thick sputum

clear dilute sputum

itchy pharynx

spiritlessness

anorexia

fatigued limbs and low voice speaking

were graded. Quality of life of cough was graded by Les Leicester Cough Questionnaire (LCQ). Levels of CGRP

CysLTs

TNF-α and IL-8 and safety evaluation were detected before and after treatment. Result: Disappearance rate of cough in observation group was 62.5%

which was higher than 39.42% in control group (χ2=8.601

P<0.01). The average extinction time of cough in observation group was shorter than that in control group (P<0.01). The total effective rate of traditional Chinese medicine in observation group was 97.5%

which higher than 83.54% in control group (χ2=9.061

P<0.01). After treatment

scores of cough degree for day and night and visual analogy score (VAS) in observation group were lower than those in control group (P<0.01). After treatment

scores of LCQ scale (physiology

psychology

society) and total scores in observation group were higher than those in control group (P<0.01). After treatment

levels of CGRP

CysLTs

TNF-α and IL-8 in observation group were lower than those in control group (P<0.01). There was no untoward effect related to Xiaoer Feike granule. Conclusion: Xiaoer Feike granule can effectively relieve cough

shorten cough course

increase the cough disappearance rate and the clinical curative effect of traditional Chinese medicine

and significantly improve the patients' quality of life. Its mechanism may be related to down-regulation of CGRP

CysLTs

TNF-α and IL-8 levels

reduction of airway inflammatory response

airway hyperresponsiveness and the cough reflex sensitivity.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Clinical Study of Internal and External Treatment of Gegen Qinlian Wutan Decoction in Active Ulcerative Colitis

Suhuang Zhike Capsule in the Treatment of Acute Exacerbation of Chronic Bronchitis Clinical Observation

Effect of Xuanfei Pingchuan Capsules on Rat COPD Model

Clinical Efficacy on Modified Prescription of Danggui Shaoyao San Combined with Yiyi Fuzi Baijiang San in Treating Moderate or Severe Acne with Damp-heat Blood Syndrome

Effects of Qinda Decoction on Plasma Fibrinogen and Serum Inflammatory Cytokines and Plasma Fibrinogen of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Related Author

WANG Yan-mei

KANG Mei-qing

CUI Yan-bing

XING Zhi-xia

WANG Rui-fang

XU Jian-xin

WANG Hong-yu

GUO Xin

Related Institution

Hainan Provincial People's Hospital

Hainan Children's Hospital

Haikou Hospital of Traditional Chinese Medicine

Quality Control Office,Armed Police Corps Hospital of Henan

Fraditional Chinese Medicine Hospital of Zhongmu County,Zhongmu

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰