Effect of Anthocyanins on Signal Transduction Pathway of Inflammatory Cytokines in Lung Cancer Cell

LIU Si-yuan; LI Zhi-peng; PENG Zhao-yun; ZHANG Feng-yan; HAN Qun; ZHENG Xin

doi:10.13422/j.cnki.syfjx.2017140219

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Effect of Anthocyanins on Signal Transduction Pathway of Inflammatory Cytokines in Lung Cancer Cell

更新时间：2024-01-04

- Effect of Anthocyanins on Signal Transduction Pathway of Inflammatory Cytokines in Lung Cancer Cell
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 14, Pages: 219-225(2017)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.2017140219
  CLC： R285
- Published：2017
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LIU Si-yuan, LI Zhi-peng, PENG Zhao-yun, et al. Effect of Anthocyanins on Signal Transduction Pathway of Inflammatory Cytokines in Lung Cancer Cell[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(14): 219-225.
DOI：

LIU Si-yuan, LI Zhi-peng, PENG Zhao-yun, et al. Effect of Anthocyanins on Signal Transduction Pathway of Inflammatory Cytokines in Lung Cancer Cell[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(14): 219-225. DOI： 10.13422/j.cnki.syfjx.2017140219.

摘要

花青素（anthocyanin）是一类广泛存在于植物中的水溶性天然色素。目前研究发现，花青素具有抗炎、抗氧化、抗衰老、抗增殖功效，能够选择性的抑制癌细胞的生长，降低心血管疾病等。花青素可通过抑制白细胞介素（IL），环氧酶-2（COX-2），核转录因子-κB（NF-κB）等的表达实现其生物功能。肺癌作为我国恶性肿瘤中发病率和死亡率最高的疾病，其发生发展在一定程度上与局部的持续炎症状态有关。目前，在肺癌的综合治疗模式中，中医药能够明显增强整体的治疗疗效。炎症又被称为“癌症的第7大特征”，在炎症和肿瘤中发挥重要作用。IL-6，COX-2，肿瘤坏死因子-α（TNF-α）等炎性因子与肺癌的发生发展密切相关。在炎症与肺癌的关系中，存在着多种信号转导通路，其中与肺癌发展较为密切的主要是NF-κB和两面神激酶（Janus kinase，JAK）/信号传导及转录激活因子（STAT）通路。IL-6是一种多效性细胞因子，在信号传递过程中，丝裂原活化蛋白激酶（MAPK），STAT以及磷脂酰肌醇3激酶（PI3K）等信号途径中的多种蛋白参与了IL-6在靶细胞中的信号转导，形成癌蛋白（Ras）/MAPK途径，JAK/STAT途径，PI3K等介导的信号通路而发挥其生物学功能。某些细胞内外刺激因子可使COX-2表达急剧增加，产生前列腺素类物质如前列腺素E2（PGE2）等。肿瘤细胞内PGE2合成分泌增加后，可促进细胞增殖、迁移及抑制肿瘤细胞凋亡。近年来诸多研究认为，IL-6和COX-2与花青素的功能实现有关，且IL-6和COX-2的信号传导相互影响，而这些细胞因子的详细作用机制可能为肺癌的治疗提供新方法。本文主要介绍花青素对肺癌细胞相关炎性因子信号转导通路作用的目前的研究状况。

Abstract

Anthocyanin is a type of soluble natural pigments that widely exists in plants. The current study shows that anthocyanin has anti-inflammatory

antioxidant

anti-aging and anti-proliferation effects

and can selectively inhibit the growth of cancer cells and reduce cardiovascular disease. Anthocyanin can realize its biological functions by inhibiting expressions of interleukin (IL)

cyclooxygenase-2 (COX-2) and nuclear factor-kappa B (NF-κB). Lung cancer has the highest incidence and mortality among malignant tumors in our country. The occurrence and development of lung cancer is correlated with the persistent inflammation to some extent. At present

traditional Chinese medicine (TCM) could enhance the overall efficacy in treating lung cancer. Inflammation

which is also called ‘the seven main characteristics of cancer’

plays an important role in the development of cancer. IL-6

COX-2

tumor necrosis factor-α(TNF-α) are closely related to the occurrence and development of lung cancer. In the relationship between inflammation and lung cancer

there are many signal transduction pathways

and the development of lung cancer is closely correlated with NF-κB and Janus kinase (JAK)/STAT pathway. IL-6 is a pleiotropic cytokine in the signal transmission process. A variety of proteins

like MAPK

STAT and phosphatidylinositol-3-kinases (PI3K)

involve in the signal transduction of IL-6 and the formation of Ras/MAPK pathway

JAK/STAT pathway and PI3K-mediated pathway. Some cell stimulating factors can increase dramatically the expression of COX-2

and produce prostaglandins

such as prostaglandin E2 (PGE2). PGE2 can promote cell proliferation and migration

and inhibit apoptosis of tumor cells. Many studies in recent years have shown that IL-6 and COX-2 are correlated with the realization of anthocyanin's effect

and there are interactions between IL-6 and COX-2 signal transduction. The detailed mechanism of action of these cytokines may provide a new method for the treatment of lung cancer. This paper introduces some of recent studies on the effect of anthocyanins on inflammatory factor signal transduction pathways related to lung cancer cells.

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