Comparison of Intestinal Absorption in Rats of Saponins in Three Kinds of Notoginseng Radix et Rhizoma Samples

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Comparison of Intestinal Absorption in Rats of Saponins in Three Kinds of Notoginseng Radix et Rhizoma Samples

更新时间：2024-01-04

- Comparison of Intestinal Absorption in Rats of Saponins in Three Kinds of Notoginseng Radix et Rhizoma Samples
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 15, Pages: 10-14(2017)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2017150010
  CLC： R285.5
- Published：2017
- 稿件说明：
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LI Dan-hui, WANG Yue, LI Han-yue, et al. Comparison of Intestinal Absorption in Rats of Saponins in Three Kinds of Notoginseng Radix et Rhizoma Samples[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(15): 10-14.
DOI：

LI Dan-hui, WANG Yue, LI Han-yue, et al. Comparison of Intestinal Absorption in Rats of Saponins in Three Kinds of Notoginseng Radix et Rhizoma Samples[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(15): 10-14. DOI： 10.13422/j.cnki.syfjx.2017150010.

摘要

目的：比较三七原枝粉、超微粉、破壁粉中三七皂苷R1，人参皂苷Rg1，人参皂苷Rb1的大鼠在体小肠吸收差异，为该药材的原料筛选提供依据。方法：采用大鼠在体循环灌流法，运用HPLC同时测定肠循环灌流液中三七皂苷R1，人参皂苷Rg1，人参皂苷Rb1及酚红的含量，研究3种三七样品中三七皂苷R1，人参皂苷Rg1和人参皂苷Rb1在大鼠小肠的吸收情况。结果：三七原枝粉、超微粉、破壁粉中三七皂苷R1的吸收速率常数（Ka）分别为0.049 80，0.037 37，0.034 60 h-1，人参皂苷Rg1的Ka分别为0.044 83，0.032 48，0.036 50 h-1，人参皂苷Rb1的Ka分别为0.078 40，0.095 48，0.084 78 h-1；三七皂苷R1的吸收率（P）分别为9.543%，7.662%，5.858%，人参皂苷Rg1的P分别为8.602%，7.154%，6.667%，人参皂苷Rb1的P分别为14.60%，17.86%，15.64%。对于三七皂苷R1的吸收，三七超微粉、破壁粉与原枝粉相比Ka和P均变小且存在显著性差异；对于人参皂苷Rg1的吸收，三七超微粉、破壁粉与原枝粉相比Ka和P均变小；对于人参皂苷Rb1的吸收，三七超微粉、破壁粉与原枝粉相比Ka和P均变大且超微粉存在显著性差异。结论：3种三七粉中三七皂苷R1，人参皂苷Rg1和人参皂苷Rb1在大鼠小肠的吸收量和吸收速率均存在一定差异，但三七超微粉和破壁粉的吸收情况并不比三七原枝粉好，建议原料选择三七原枝粉。

Abstract

Objective: To compare the difference of in situ small intestinal absorption in rats of notoginsenoside R1

ginsenoside Rg1 and ginsenoside Rb1 in original powder

ultra-fine powder and cell wall-broken powder of Notoginseng Radix et Rhizoma. Method: In situ perfusion method in rats was adopted

the concentration of notoginsenoside R1

ginsenoside Rg1

ginsenoside Rb1 and phenol sulfonphthalein in intestinal circulating perfusate were determined simultaneously by HPLC

which is used to study on the absorption of notoginsenoside R1

ginsenoside Rg1and ginsenoside Rb1 from Notoginseng Radix et Rhizoma samples in the small intestine of rats. Result: The absorption rate constants (Ka) of notoginsenoside R1 in the original powder

ultra-fine powder and cell wall-broken powder were 0.049 80

0.037 37

0.034 60 h-1

Ka of ginsenoside Rg1 were 0.044 83

0.032 48

0.036 50 h-1

Ka of ginsenoside Rb1 were 0.078 40

0.095 48

0.084 78 h-1

respectively.The absorption percentages (P) of notoginsenoside R1 were 9.543%

7.662%

5.858%

those of ginsenoside Rg1 were 8.602%

7.154%

6.667%

those of ginsenoside Rb1 were 14.60%

17.86% and 15.64%

respectively. Conclusion: There are differences in the absorption amount and rate of notoginsenoside R1

ginsenoside Rg1 and ginsenoside Rb1 in three kinds of Notoginseng Radix et Rhizoma powder

but the absorption of ultra-fine powder and cell wall-broken powder has no significant superiority by comparing with the original powder

selection of original powder as raw material is better.

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Related Institution

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