Objective: To explore the therapeutic effect of Sanbitang recipe in treating lumbar disc Herniation (LDH) case with cold-dampness syndromeand its safety. Method: A total of 192 cases with cold-dampness syndrome were randomly divided into the traditional Chinese medicine(TCM) group

the western medicine group and the traditional Chinese and western medicine group

with 64 cases in each group. The TCM group was treated with Sanbitang. Etoricoxib tablets were applied in the western medicine group. Sanbitang and etoricoxib tablets were adopted in the traditional Chinese and western medicine group.One course of treatment was 28 d. Meliorate-Japanese orthopaedic association (M-JOA)

oswestry disability index (ODI)

visual analogue scale (VAS) and TCM cold-dampness syndrome score (TCM syndrome score) were analyzed to estimate the efficacy of three group before and after treatment.Tumor necrosis factor-α(TNF-α)

interleukins-β(1L-1β)

C-reactive protein (CRP) and superoxide dismutase (SOD) were detected.The efficient rates and adverse event rates among three groups were compared. Result: The total effective rate of the Chinese and western medicine group was 95.1%

which was better than TCM group (79.4%) and the chemical medicine group (82.3%

P<0.05). After treatment

as for the score of radiotherapy

the traditional Chinese and western medicine group and the TCM group were better than western medicine group (P<0.05). Regarding the other symptoms

the traditional Chinese and western medicine group showed more significant alleviations (P<0.05). The adverse event rate of the TCM group was the lowest among three groups (P<0.05). Conclusion: Modified Sanbitang is effective in treating LDH caseswith cold-dampness syndrome.To compare with western medicine Etoricoxib tablets

it shows no obvious difference and fewer adverse events.Sanbitang recipe shows a remarkable efficacy in treating LDH caseswith cold-dampness syndrome.