Effect of Shashen Maidong Tang Combined with Chemotherapy on Immune Function and Inflammatory Reaction of Patients with Lung Cancer of Qi and Yin Deficiency

YANG Zhong-guang; LIANG Xin; ZHAO Yuan-qiao

doi:10.13422/j.cnki.syfjx.2017160158

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Effect of Shashen Maidong Tang Combined with Chemotherapy on Immune Function and Inflammatory Reaction of Patients with Lung Cancer of Qi and Yin Deficiency

更新时间：2024-01-04

- Effect of Shashen Maidong Tang Combined with Chemotherapy on Immune Function and Inflammatory Reaction of Patients with Lung Cancer of Qi and Yin Deficiency
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 16, Pages: 158-163(2017)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.2017160158
  CLC： R734.2
- Published：2017
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YANG Zhong-guang, LIANG Xin, ZHAO Yuan-qiao. Effect of Shashen Maidong Tang Combined with Chemotherapy on Immune Function and Inflammatory Reaction of Patients with Lung Cancer of Qi and Yin Deficiency[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(16): 158-163.
DOI：

YANG Zhong-guang, LIANG Xin, ZHAO Yuan-qiao. Effect of Shashen Maidong Tang Combined with Chemotherapy on Immune Function and Inflammatory Reaction of Patients with Lung Cancer of Qi and Yin Deficiency[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(16): 158-163. DOI： 10.13422/j.cnki.syfjx.2017160158.

摘要

目的：观察沙参麦冬汤联合化疗对气阴两虚型肺癌患者免疫功能及炎性反应的影响，并探讨其作用机制。方法：收集遵义市中医院就诊或住院治疗的110例非小细胞肺癌患者，随机分为治疗组和对照组，每组55例。两组患者入院后均给予相应的治疗措施，对照组患者给予吉西他滨+顺铂的化疗方案，治疗组患者在对照组的基础上给予沙参麦冬汤200 mL/次，1剂/d，清水煎服，早晚分服。治疗21 d为1个周期，连续两个周期。观察并比较两组患者治疗前后血清CD4+，CD8+，CD4+/CD8+，自然杀伤细胞（natural killer cell，NK），白细胞介素-6（interleukin-6，IL-6），肿瘤坏死因子-α （tumor necrosis factor-α，TNF-α）水平，患者临床治疗有效率，体力状况评分（Kamofsky patients health status score，KPS）和体重变化以及不良反应发生率。结果：与治疗前比较，两组患者治疗后CD8+，IL-6，TNF-α水平均下降，CD4+，CD4+/CD8+水平均升高（P <0.05）；治疗后与对照组比较，治疗组患者CD8+，IL-6，TNF-α水平降低，CD4+，CD4+/CD8+水平升高（P <0.05）；两组患者治疗前后的NK细胞水平差异无统计学意义。治疗后与对照组比较，治疗组患者临床治疗有效率，KPS评分和体重变化稳定率升高，不良反应发生率降低（P <0.05）。结论：沙参麦冬汤联合化疗能够改善气阴两虚型肺癌患者的免疫功能，降低患者体内的炎性反应，临床疗效以及安全性均较好。

Abstract

Objective: To evaluate the effect of Shashen Maidong Tang combined with chemotherapy on the immune function and inflammatory reaction of patients with lung cancer of Qi and Yin deficiency

and investigate its mechanism of action. Method: The 110 patients with non small cell lung cancer in Zunyi Hospital of Traditional Chinese Medicine were randomly divided into treatment group and control group

55 cases in each group. Both groups of patients were given with corresponding treatment measures. The patients in control group were treated with chemotherapy of gemcitabine+cisplatin

and the patients in treatment group were treated with Shashen Maidong Tang on the basis of the treatment in control group

200 mL/time

1 dose/d

one time in the morning and one time in the evening. 21 days were regarded as one treatment course

and they were treated for two consecutive courses in both groups. Serum CD4+

CD8+

CD4+/CD8+

natural killer cell (NK)

interleukin-6 (IL-6)

tumor necrosis factor-α (TNF-α)

effective rate

Kamofsky patients health status score (KPS)

body mass change and adverse reaction incidence were observed and compared before and after treatment in two groups. Result: As compared with the conditions before treatment

CD8+

IL-6

and TNF-α levels were decreased

and the level of CD4+

CD4+/CD8+ were increased in both groups after treatment (P <0.05). After treatment

the CD8+

IL-6

TNF-α levels were lower

while CD4+

CD4+/CD8+ levels were higher in treatment group than those in control group (P <0.05); and there was no significant difference in the level of NK cells between two groups before and after treatment. After treatment

the effective rate of clinical treatment

KPS score and body mass stable rate were higher

and incidence of adverse reactions was lower in treatment group as compared with those in control group (P <0.05). Conclusion: Shashen Maidong Tang combined with chemotherapy can improve the immune function of patients with Qi and Yin deficiency type lung cancer

and reduce the inflammatory reaction in patients

with higher clinical efficacy and safety.

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Related Institution

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