GUO Ji-fang, GAO Jing. Clinical Observation of Fangji Huangqi Tang Combined with Zhenwutang for Chronic Heart Failure with Qi Deficiency and Blood Stasis Type[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(16): 171-175.
DOI:
GUO Ji-fang, GAO Jing. Clinical Observation of Fangji Huangqi Tang Combined with Zhenwutang for Chronic Heart Failure with Qi Deficiency and Blood Stasis Type[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(16): 171-175. DOI: 10.13422/j.cnki.syfjx.2017160171.
Clinical Observation of Fangji Huangqi Tang Combined with Zhenwutang for Chronic Heart Failure with Qi Deficiency and Blood Stasis Type
目的: 观察防己黄芪汤合真武汤加减治疗慢性心力衰竭气虚血瘀型患者的临床疗效。方法: 将符合纳入标准的80例慢性心力衰竭(气虚血瘀型)患者,随机分为对照组与治疗组,各40例。对照组给予常规抗心衰西药治疗,包括血管紧张素转化酶抑制剂(angiotensin converting enzyme inhibitors,ACEI)或血管紧张素Ⅱ受体阻滞剂(angiotensin Ⅱ receptor blockers,ARB),扩血管药物,β受体阻滞剂,利尿剂,地高辛等;治疗组在常规治疗基础上加用防己黄芪汤合真武汤加减,共4周。观察两组患者治疗前与治疗后中医证候疗效、心功能分级比较、左室舒张末内径(left ventricular end diastole,LVED),左室收缩末内径(left ventricular end of systolic diameter,LVSD),左室射血分数(left ventricular ejection fraction,LVEF)。结果: 经过治疗,在中医证候疗效方面,治疗组总有效率82.5%,优于对照组的65%(P <0.05);在心功能分级比较方面,治疗组总有效率85%,优于对照组的60%(P <0.05);在心功能指标方面,对照组和治疗组LVED和LVSD均降低,LVEF上升(P <0.05);治疗组LVED和LVSD均低于对照组,LVEF高于对照组(P <0.01)。结论: 防己黄芪汤合真武汤加减在改善慢性心力衰竭患者的中医证候、心功能分级、以及改善心功能和心室重构方面具有一定作用。
Abstract
Objective: To observe the clinical efficacy of Fangji Huangqi Tang combined with Zhenwutang for chronic heart failure (Qi deficiency and blood stasis type). Method: According to the inclusion criteria
80 patients with chronic heart failure (Qi deficiency and blood stasis type) were randomly divided into control group and treatment group (40 cases in each group). The patients in control group received conventional anti-heart failure western medicine (including angiotensin converting enzyme inhibitors or angiotensin Ⅱ receptor blockers
vasodilator drugs
beta blockers
diuretics
digoxin
et al); patients in treatment group received Fangji Huangqi Tang combined with Zhenwutang on the basis of routine treatment
for a total of 4 weeks. Two groups of patients were observed before and after treatment for traditional Chinese medicine (TCM) syndrome curative effect
cardiac function grading
left ventricular end diastolic diameter (LVED)
left ventricular end systolic diameter (LVSD)
and left ventricular ejection fraction (LVEF). Result: After treatment
the total effective rate for TCM syndrome was 82.5% in treatment group
better than 65% in control group (P <0.05); the total effective rate of cardiac functions grading was 85% in treatment group
better than the 60% in control group (P <0.05); in the index of heart function
LVED and LVSD levels were decreased
and LVEF was increased in both treatment group and control group after treatment (P <0.05); the LVED and LVSD levels in treatment group were lower while LVEF was higher than those in the control group (P <0.01). Conclusion: Fangji Huangqi Tang combined with Zhenwutang has a certain role in improving TCM syndrome
cardiac functions grading
cardiac functions and ventricular remodeling in patients with chronic heart failures.