Effect of Qihuang Tongluo Decoction on Uremia Peripheral Neuropathy Based on Sympathetic Skin Reaction

LIU Wen-jun; LIN Yun; CHEN Hai-xia

doi:10.13422/j.cnki.syfjx.2017160188

您当前的位置：

首页 >

文章列表页 >

Effect of Qihuang Tongluo Decoction on Uremia Peripheral Neuropathy Based on Sympathetic Skin Reaction

更新时间：2024-01-04

- Effect of Qihuang Tongluo Decoction on Uremia Peripheral Neuropathy Based on Sympathetic Skin Reaction
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 16, Pages: 188-193(2017)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2017160188
  CLC： R277.5
- Published：2017
- 稿件说明：
移动端阅览
LIU Wen-jun, LIN Yun, CHEN Hai-xia. Effect of Qihuang Tongluo Decoction on Uremia Peripheral Neuropathy Based on Sympathetic Skin Reaction[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(16): 188-193.
DOI：

LIU Wen-jun, LIN Yun, CHEN Hai-xia. Effect of Qihuang Tongluo Decoction on Uremia Peripheral Neuropathy Based on Sympathetic Skin Reaction[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(16): 188-193. DOI： 10.13422/j.cnki.syfjx.2017160188.

摘要

目的：基于交感神经皮肤反应（SSR）评价芪黄通络汤治疗尿毒症周围神经病变（UPN）的临床疗效，并对尿毒症毒素和致炎细胞因子水平的影响方面探讨其作用机制。方法：将154例尿毒症患者随机分为观察组和对照组。两组患者均给予血液透析+血液灌流治疗；对照组采用三维B注射液，肌肉注射，2 mL/次，3次/周；和甲钴胺片，口服，0.5 mg/次，3次/d。观察组在对照组治疗的基础上加服芪黄通络汤，1剂/d。两组疗程均为3个月。采用肌电诱发电位仪测量起始潜伏期（Lat）和峰-峰波幅值（Amp），测量胫神经、腓总神经和腓肠神经的感觉神经传导速度，治疗前后各评价1次；进行治疗前后脾肾气虚，瘀血阻滞证评分；检测治疗前后甲状旁腺激素（PTH），β2-微球蛋白（β2-MG），瘦素（LP），同型半胱氨酸（Hcy）等尿毒症毒素水平；检测治疗后肿瘤坏死因子-α （TNF-α），血清C反应蛋白（CRP），白细胞介素-6（IL-6）和IL-8等致炎细胞因子水平。结果：观察组中医证候疗效总有效率为93.06%，高于对照组的74.29%（χ2=9.212，P <0.01）；治疗后观察组上、下肢Lat均短于对照组，上、下肢Amp均高于对照组（P <0.01）；治疗后观察组SSR异常率为26.39%，低于治疗前的66.67%，（χ2=23.471，P <0.01），并低于治疗后对照组的44.29%（χ2=4.983，P <0.05）；治疗后观察组胫神经、腓总神经和腓肠神经的感觉神经传导速度均快于对照组（P <0.05，P <0.01）；治疗后观察组患者血清PTH，β2-MG，LP和Hcy水平均低于对照组（P <0.01）；治疗后观察组患者血清TNF-α， CRP，IL-6和IL-8水平均低于对照组（P <0.01）。结论：采用芪黄通络汤治疗UPN患者，能改善患者神经功能，促进周围神经功能的恢复，其作用机制可能与清除尿毒症毒素和减轻炎症反应有关。

Abstract

Objective: To discuss the clinical efficacy of Qihuang Tongluo decoction on uremia peripheral neuropathy (UPN) based on sympathetic skin reaction(SSR)

and the mechanism according to uremic toxins and levels of prophylactic factors. Method: One hundred and fifty-four patients with uremia were randomly divided into control group and observation group by random number table. Both groups' patients were given hemodialysis and blood perfusion. Patients in control group got three-dimensional B injection for intramuscular injection

2 mL/time

3 times/week

methylcobalamin tablets

0.5 mg/time

3 times/day. In addition to the therapty of control group

patients in observation group were also given Qihuang Tongluo decoction

1 dose/day. One course of treatment was three months. Before and after treatment

Latency (Lat) and peak-pesk amplitude (Amp) were detected by electromyography evoked potentiometer

and sensory nerve conduction velocity of tibial nerve

peroneal nerve and sural nerve were also detected. Before and after treatment

spleen and kidney Qi deficiency and blood stasis syndrome were scored. Before and after treatment

levels of parathyroid hormone (PTH)

β2-microglobulin (β2-MG)

leptin (LP)

homocysteine (Hcy)

tumor necrosis factor-α (TNF-α)

serum C-reactive protein (CRP)

interleukin-6 (IL-6) and interleukin-8 (IL-8) were also detected. Result: The total effect rate of traditional Chinese medicine(TCM) in observation group was 93.06%

which was higher than 74.29% in control group (χ2=9.212

P <0.01). Lat of upper and lower limbs in observation group were shorter than those in control group

and Amp of upper and lower limbs in observation group were longer than those in control group (P <0.01). After treatment

the abnormality rate of SSR in observation group was 26.39%

which was lower than 66.67% in control group before treatment (χ2=23.471

P <0.01)

and 44.29% in control group after treatment (χ2=4.983

P <0.01). After treatment

sensory nerve conduction velocity of tibial nerve

common peroneal nerve and sural nerve in observation group were all faster than those in control group (P <0.05 or P <0.01). Levels of PTH

β 2-MG

Hcy

TNF-α

CRP

IL-6

IL-8 were lower than those in control group (P <0.01). Conclusion: Qihuang Tongluo decoction can improve the patient's neurological function

and promote the recovery of peripheral nerve function. Its mechanism may be related to the removal of uremic toxins and the reduction of inflammatory responses.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Signaling Pathways Related to Diabetic Peripheral Neuropathy Treated by Chinese Medicine： A Review

Clinnical Study of Tangmaining Capsule in the Treatment of Diabetic Peripheral Neuropathy

Effect of Tangbian Foot therapy on Vibration Threshold in Patients with Diabetes

Effect of Chinese Herbal Compound Tangbikang on Expressions of NGF Protein and NGF mRNA of Diabetic Rats’ Sciatic Nerve

Related Author

GUAN Xuefeng

CHEN Chongmin

YANG Yongju

ZHANG Xiwei

SUN Yu

YAO Sicheng

Li Lan-fang1

He Wei2

Related Institution

Liaoning University of Traditional Chinese Medicine（TCM）

Shenyang Orthopedic Hospital

The Affiliated Hospital of Liaoning University of TCM

Liaoning University of Traditional Chinese Medicine

The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰