LIU Xin-kui, WU Jia-rui, LIN Meng-juan, et al. Mechanism of Si Junzitang Based on Network Pharmacology[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(16): 194-202.
DOI:
LIU Xin-kui, WU Jia-rui, LIN Meng-juan, et al. Mechanism of Si Junzitang Based on Network Pharmacology[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(16): 194-202. DOI: 10.13422/j.cnki.syfjx.2017160194.
Mechanism of Si Junzitang Based on Network Pharmacology
Objective: To investigate the efficacy and compatibility mechanism of Si Junzitang. Method: Chemical components
targets and diseases related to the four traditional Chinese medicine (TCM) herbs were searched through the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). Compound-target network
target-disease network
protein-protein interaction(PPI) network
and target-pathway network were constructed to explore the mechanism of Si Junzitang. Result: Totally 27 components
93 targets and 215 diseases related to the four TCM herbs were obtained through screening. The PPI network contains 68 targets
in which key targets involving FOS
ESR1
AR
PPARG and so on. There were 121 gene ontology(GO) entries
including 96 biological process entries
13 molecular function entries and 12 cellar component entries. Besides
there were 3 KEGG pathways
involving Neuroactive ligand-receptor interaction
calcium signaling pathway and cancer pathway. Conclusion: The result of the study preliminarily verifies the basic pharmacological effects and related mechanisms of Si Junzitang
in order to lay a solid foundation for further studies on the mechanism of action.
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Related Author
FAN Yao-hua
OU Hai-ya
WANG Han-yu
LYU Dong-yong
LIAN Yi-qing
HOU Jiang-tao
KUANG Wei-hong
LI Shanshan
Related Institution
Key Laboratory for Research and Evaluation of Traditional Chinese Medicine, National Medical Products Administration,Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences
Liaoning Herbapex Pharmaceutical(Group) Co. Ltd.
Beijing Key Laboratory of Traditional Chinese Medicine(TCM) Quality Evaluation, Beijing University of Chinese Medicine
School of TCM, Beijing University of Chinese Medicine