LIU Xin-kui, WU Jia-rui, LIN Meng-juan, et al. Study on Mechanism of Wuzhuyu Tang Based on Network Pharmacology[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(16): 203-210.
DOI:
LIU Xin-kui, WU Jia-rui, LIN Meng-juan, et al. Study on Mechanism of Wuzhuyu Tang Based on Network Pharmacology[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(16): 203-210. DOI: 10.13422/j.cnki.syfjx.2017160203.
Study on Mechanism of Wuzhuyu Tang Based on Network Pharmacology
Objective: To investigate the efficacy and compatibility mechanism of Wuzhuyu Tang. Method: The chemical components and targets related to the four Chinese herbal medicines were searched from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). The compound-target network
protein-protein interaction(PPI) network
and target-pathway network were constructed to explore the mechanism of Wuzhuyu Tang. Result: The compound-target network contain 29 chemicalcomponents and 77 targets. The hub targets involve PTGS2
PTGS1 and so on.The PPI network contain 70 proteins
in which the hub proteins involve AP-1
BCL2
HSP90α and so on. In the gene ontology(GO) functional enrichment analysis
and pathways in cancer. Conclusion: The result of the study preliminarily verifies the basic pharmacological effects and related mechanisms of Wuzhuyu Tang
thuslaying a solid foundation for deeply study on the mechanism of action.
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