Mechanism of Shenfutang Based on Network Pharmacology

LIU Xin-kui; WU Jia-rui; ZHANG Dan; ZHANG Xiao-meng

doi:10.13422/j.cnki.syfjx.2017160211

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Mechanism of Shenfutang Based on Network Pharmacology

更新时间：2024-01-04

- Mechanism of Shenfutang Based on Network Pharmacology
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 16, Pages: 211-218(2017)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.2017160211
  CLC： R285
- Published：2017
- 稿件说明：
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LIU Xin-kui, WU Jia-rui, ZHANG Dan, et al. Mechanism of Shenfutang Based on Network Pharmacology[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(16): 211-218.
DOI：

LIU Xin-kui, WU Jia-rui, ZHANG Dan, et al. Mechanism of Shenfutang Based on Network Pharmacology[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(16): 211-218. DOI： 10.13422/j.cnki.syfjx.2017160211.

摘要

目的：探讨参附汤的功效物质基础和作用机制。方法：依托中药系统药理学分析平台（TCMSP）检索参附汤2味中药人参、附子的化学成分和作用靶点。进而构建化合物-靶点网络、构建蛋白互作（PPI）网络、进行基因本体（GO）功能富集分析、进行基于京都基因与基因组百科全书（KEGG）通路富集分析，研究参附汤作用机制。结果：化合物-靶点网络包含23个化合物和相应靶点118个，关键靶点涉及PTGS2，PTGS1，NCOA2，ADRB2等。PPI网络包含114个蛋白，关键蛋白涉及Akt，AP-1，p56蛋白等。GO功能富集分析得到GO条目236个，其中生物过程相关的条目191个，分子功能相关的条目20个，细胞组成相关的条目25个。KEGG通路富集筛选得到10条信号通路涉及calcium signaling pathway，neuroactive ligand-receptor interaction，apoptosis，pathways in cancer等。结论：本研究结果初步验证参附汤防治疾病的分子机制，为进一步深入探讨其作用机制提供先导信息和基础。

Abstract

Objective: To investigate the efficacy and mechanism of Shenfutang. Method: The chemical components and corresponding targets related to Shenfutang were searched from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). The compound-target network and the protein-protein interaction(PPI) network were established

and the GO functional enrichment analysis and the KEGG pathway enrichment analysis were made to explore the mechanism of Shenfutang. Result: The compound-target network contained 23 chemical components and 118 targets. The hub targets involved PTGS2

PTGS1

NCOA2

ADRB2.The PPI network contained 114 proteins

in which the hub proteins involved AKT

AP-1

p56.The GO functional enrichment analysis showed 236 GO entries (including 191 for biological process

20 for molecular function

25 for cellar component). The KEGG pathway enrichment analysis showed 10 pathways

involving calcium signaling pathway

neuroactive ligand-receptor interaction

apoptosis

and pathways in cancer. Conclusion: The result of the study preliminarily verifies the basic pharmacological effects and related mechanisms of Shenfutang

thus laying a solid foundation for further study on the mechanism of action.

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