Isolation and Identification of Chemical Constituents from Stems of

YANG Bing-you; LU Zhen-kun; LIU Yan; GUO Hong-wei; KUANG Hai-xue

doi:10.13422/j.cnki.syfjx.2017170034

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Isolation and Identification of Chemical Constituents from Stems of

更新时间：2024-01-04

- Isolation and Identification of Chemical Constituents from Stems of
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 17, Pages: 34-40(2017)
- 作者机构：
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- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2017170034
  CLC： R284.1
- Published：2017
- 稿件说明：
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YANG Bing-you, LU Zhen-kun, LIU Yan, et al. Isolation and Identification of Chemical Constituents from Stems of [J]. Chinese journal of experimental traditional medical formulae, 2017, 23(17): 34-40.
DOI：

YANG Bing-you, LU Zhen-kun, LIU Yan, et al. Isolation and Identification of Chemical Constituents from Stems of [J]. Chinese journal of experimental traditional medical formulae, 2017, 23(17): 34-40. DOI： 10.13422/j.cnki.syfjx.2017170034.

摘要

目的：研究洋金花Datura metel茎的化学成分。方法：采用硅胶，ODS柱色谱及HPLC等色谱分离方法进行分离纯化，利用NMR，HR-ESI-MS等波谱学方法结合参考文献鉴定化合物的结构。结果：从洋金花茎70%乙醇提取物的乙酸乙酯萃取部位中分离得到14个化合物，分别鉴定为N-[2-（3，4-dihydroxyphenyl-2-hydroxyethyl）]-3-（4-methoxyphenyl） prop-2-enamide（1），3-（4-hydroxy-3-methoxyphenyl）-N-[2-（4-hydroxyphenyl）-2-methoxyethyl] acrylamide（2），N-反式-对-香豆酰基章鱼胺（3），N-顺式阿魏酰基酪胺（4），N-trans-feruloyl-3'，4'-dihydroxyphenylethylamine（5），N-反式阿魏酰基酪胺（6），N-反式-对-香豆酰基酪胺（7），草夹竹桃苷（8），daturataturin A（9），baimantuoluoside H（10），daturametelin A（11），柑橘苷 A（12），9，12，13-三羟基-10，15-十八碳二烯酸甲酯（13），（9E）-8，11，12-三羟基-十八碳烯酸甲酯（14）。结论：化合物 1，8 为首次从茄科植物中分离得到，化合物 2~5 为首次从曼陀罗属植物中分离得到。

Abstract

Objective: To study the chemical constituents from the stems of Datura metel. Method: The compounds were isolated and purified by silica gel and ODS chromatogram columns together with semi-preparative HPLC. The structures of the isolated compounds were identified by 1H-NMR and 13 C-NMR as well as HR-ESI-MS data. Result: Fourteen compounds were isolated from the ethyl acetate fraction of the 70% ethanol extract from the stems of D. metel

which were identified as N-[2-(3

4-dihydroxyphenyl-2-hydroxyethyl)]-3-(4-methoxyphenyl) prop-2-enamide (1)

3-(4-hydroxy-3-methoxyphenyl)-N-[2-(4-hydro-xyphenyl)-2-methoxyethyl] acrylamide (2)

N-trans-p-coumaroyloctopamine (3)

N-cis-feruloyltyramine (4)

N-trans-feruloyl-3'

4'-dihy-droxyphenylethylamine (5)

N-trans-feruloyl tyramine (6)

trans-N-p-coumaroyltyramine (7)

androsin (8)

daturataturin A (9)

baimantuoluoside H (10)

daturametelin A (11)

citroside A (12)

methyl-9

13-trihydroxyoctadeca-10

15-dienoate (13) and (9E)-8

12-trihydroxyoctadecenoic acid methyl ester (14). Conclusion: Compounds 1 and 8 were isolated from the plants of Solanaceae for the first time and compounds 2 - 5 were isolated from Datura genus for the first time.

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