Objective: To study the clinical efficacy of Jianpi Liqi Huashi dispensing granules in nonalcoholic steatohepatitis patients with syndrome of spleen-deficiency and damp-heat and investigate its effect on free acid (FFA)

homeostasis model of assessment for insulin resistance (HOMA-IR) and aspartate aminotransferase to platelet ratio index (APRI). Method: According to the standard

96 nonalcoholic steatohepatitis patients with syndrome of spleen-deficiency and dampness-heat were enrolled and randomly assigned to control group and treatment group according to 1: 1 ratio by using random number table

48 patients in each group. Based on the exercise and diet adjustment

patients in control group received placebo granules

and the patients in treatment group received Jianpi Liqi Huashi dispensing granules. Treatment course was 24 weeks for both groups. Relevant examinations were performed before and after treatment to evaluate the efficacy

and the changes of FFA

HOMA-IR and APRI were observed. Result: The total effective rate was 82.5% in treatment group

higher than 52.5% in control group (P<0.01). After treatment

FFA levels were significantly decreased in both groups (P<0.05

P<0.01)

and the decrease was more obvious in treatment group (P<0.01); HOMA-IR levels were significantly decreased than those before treatment in both groups (P<0.01)

and the decrease in treatment group was more obvious (P<0.01). As compared with before treatment

APRI level was slightly decreased in control group after treatment

but the difference was not statistically significant

and APRI level was significantly decreased in treatment group

significantly lower than that in control group (P<0.01). Conclusion: Jianpi Liqi Huashi dispensing granules has good curative effect for nonalcoholic steahepatitis patients with syndrome of Spleen-deficiency and damp-heat

can significantly reduce the level of FFA

and improve insulin resistance and liver fibrosis.