Objective: To discuss the clinical efficacy of add and subtract dialectics of Huposan on endometriosis (EMs) with blood stasis syndrome and investigate its effect on inflammation factors. Method: One hundred and thirty-eight patients with EMs were randomly divided into control group 69 cases and observation group 69 cases by random number table. The control group adopted mifepristone

12.5 mg/time

1 time/day. In observation group

the patients received add and subtract dialectics of Huposan

1 dose/day. The treatment course was 6 months in both groups. Score of pain in menstrual period was graded by visual simulation score (VAS)

and scores of pelvic pain

sexual intercourse pain

pelvic tenderness

sacral ligament tenderness nodules and blood stasis syndrome were graded at non-menstrual period both before ans after treatment. In addition

the levels of serum thromboxane-2 (TXB2)

6-Keto prostaglandins F1α (6-Keto-PGF1α)

cancer antigen 125 (CA125)

estrogen (E2)

tumor necrosis factor-α (TNF-α)

interleukin-6 (IL-6)

and interleukin-8 (IL-8) were detected both before and after treatment. Result: The total effective rate was 95.38% in observation group

higher than 81.25% in control group (χ2=6.269

P<0.05). In the variance analysis of repeated measurements

during 6 menstrual cycles

scores of VAS were decreased(Fcontrol=6.903

Fobservation＝7.632

P<0.05). In paired t-test

at the 3th

4th

5th and 6th menstrual cycles

scores of VAS in observation group were lower than those in control group (P<0.01). After treatment

scores of pelvic pain

pain in intercourse

pelvic tenderness

tenderness of the sacral ligament

and blood stasis scores

and levels of CA125

E2

TXB2 and 6-Keto-PGF1α

TNF-α

IL-6

and IL-8 in observation group were all lower than those in control group (P<0.01). Conclusion: Add and subtract dialectics of Huposan can ameliorate pain and decrease levels of estrogen

TNF-α

IL-6

and IL-8 to ameliorate conditions in patients with endometriosis pain (blood stasis syndrome).