Objective: To investigate effect of borneol on in vitro release and percutaneous absorption behavior of compound Chinese medicine eczema cremor

and to explore the feasibility of composition improvement of this compound.Method: Modified Franz diffusion device was employed with isolated BALB/c nude mice skin as a barrier

in vitro percutaneous absorption effectiveness of compound Chinese medicine eczema cremor with or without borneol was compared by in vitro percutaneous test.HPLC was used to determine the content of matrine with mobile phase of acetonitrile-water (containing 0.05% triethylamine

adjusting pH to 3.5 with phosphoric acid) (2:98) and detection wavelength at 220 nm.Result: Cumulative permeation amount of matrine in the cremor with borneol at various time points after administration was higher than that in cremor without borneol.In vitro percutaneous absorption behaviors of matrine in cremor with or without borneol were in line with zero-level process

in vitro percutaneous penetration in 12 h nearly constant speed.Cumulative permeability of matrine in cremor with borneol was 6.37% in 12 h

while that of matrine in cremor without borneol was 4.99%.Conclusion: Borneol has a certain promoting effect on transdermal absorption of matrine in compound Chinese medicine eczema cremor

and it can be added into the original compound.