SUN Jun-wei, LIU Qing-ping, LI Nan, et al. Effect of Tongfeng Decoction in Treating Gout with Moist Heat and Blood Stasis Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(18): 186-190.
DOI:
SUN Jun-wei, LIU Qing-ping, LI Nan, et al. Effect of Tongfeng Decoction in Treating Gout with Moist Heat and Blood Stasis Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(18): 186-190. DOI: 10.13422/j.cnki.syfjx.2017180186.
Effect of Tongfeng Decoction in Treating Gout with Moist Heat and Blood Stasis Syndrome
Objective: To observe the effect of Tongfeng decoction in treating gout patients with moist heat and blood stasis syndrome treated
in order to evaluate the efficacy and safety of Tongfeng decoction in treating acute gout.Method: With a randomized
parallel-controlled approach
one hundred and twenty gout patients were divided into control group and observation group. Patients in control group were treated with celecoxib 0.2 g
twice a day. Patients in observation group were treated with celecoxib 0.2 g
twice a day
and combined with Tongfeng decoction
one dose a day. Both groups received therapy for 2 weeks. The changes in score of joint gall in rest
score of joint tenderness
score of joint swollen
gross score
index of joint gall
score of joint function
serum levels of C-reactive protein
erythrocyte sedimentation rate
D-dimer and uric acid
life quality (SF-36)
and adverse reactions were recorded.Result: After treating for two weeks
the total effective rate in observation group was 87.27%
which was superior to 66.04% in control group (χ2=7.536
P<0.05). The score of joint gall in rest
score of joint tenderness
score of joint swollen
gross score
score of joint function
serum levels of C-reactive protein
erythrocyte sedimentation rate
D-dimer and uric acid in observation group were lower than those in control group (P<0.05). Index of joint gall and life quality in observation group were higher than those in control group (P<0.05). The rate of adverse reactions between control group and observation group had no statistical difference.Conclusion: Tongfeng decoction combined with celecoxib shows a positive effect in treating gout patients with moist heat and blood stasis syndrome. The Tongfeng decoction has strong anti-inflammatory activity and security. It can reduce the serum level of uric acid
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