Effect of Colon-targeted Huchang Qingdu Pellets in Blocking Intestinal Endotoxemia in Patients with HBV-related Acute on Chronic Liver Failure with Syndrome of Interior Stasis Toxin
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Effect of Colon-targeted Huchang Qingdu Pellets in Blocking Intestinal Endotoxemia in Patients with HBV-related Acute on Chronic Liver Failure with Syndrome of Interior Stasis Toxin
Chinese Journal of Experimental Traditional Medical FormulaeVol. 23, Issue 18, Pages: 191-197(2017)
ZHANG Xiang-lei, LU Li-wei, HU Dong-qing, et al. Effect of Colon-targeted Huchang Qingdu Pellets in Blocking Intestinal Endotoxemia in Patients with HBV-related Acute on Chronic Liver Failure with Syndrome of Interior Stasis Toxin[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(18): 191-197.
DOI:
ZHANG Xiang-lei, LU Li-wei, HU Dong-qing, et al. Effect of Colon-targeted Huchang Qingdu Pellets in Blocking Intestinal Endotoxemia in Patients with HBV-related Acute on Chronic Liver Failure with Syndrome of Interior Stasis Toxin[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(18): 191-197. DOI: 10.13422/j.cnki.syfjx.2017180191.
Effect of Colon-targeted Huchang Qingdu Pellets in Blocking Intestinal Endotoxemia in Patients with HBV-related Acute on Chronic Liver Failure with Syndrome of Interior Stasis Toxin
Objective: To observe the curative effect of colon-targeted Huchang Qingdu pellets in blocking intestinal endotoxemia in patients with HBV-related acute on chronic liver failure
and investigate the possible mechanism.Method: Totally 120 cases of HBV-related acute on chronic liver failure with intestinal endotoxemia (IETM) and syndrome of interior stasis toxin were collected from January 2013 to October 2016.According to double-blind double-dummy randomized control principle
these patients were divided into oral colon-targeted Huchang Qingdu pellets group
lactulose group and control group
with 40 cases in each group. Some clinical indices
such as traditional Chinese medicine (TCM) clinical symptom score
plasma endotoxin
tumor necrosis factor-α(TNF-α)
interleukin (IL)-1
IL-6
IL-8
plasma D-lactic acid
plasma diamine oxidase (DAO)
coagulation function and L/M were observed before and after treatment. And differences among the three groups were compared.Result: The clinical indices of TCM syndrome integral
plasma endotoxin
inflammatory cytokines
plasma D-lactic acid
and plasma diamine oxidase in treatment groups were significantly superior to those before treatment and in control group (P<0.05). Colon-targeted Huchang Qingdu pellets group was more effective than lactulose group in TCM syndrome score
TBIL
PA
PTA
plasma endotoxin
inflammatory cytokines
plasma D-lactic acid
and plasma diamine oxidase (P<0.05).Conclusion: Colon-targeted Huchang Qingdu pellets can inhibit the release of inflammatory cytokine
correct the permeability of the intestinal mucosa
regulate blood coagulation function and internal environment
so as to effectively prevent the occurrence of intestinal endotoxemia
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Related Author
Jie WANG
Bin CHEN
Wei ZHOU
Wu LI
Xu-chu SU
Jie PENG
Yue ZHOU
Shan DU
Related Institution
Hunan University of Chinese Medicine
Jinhua Hospital of Traditional Chinese Medicine
The First Affiliated Hospital of Hunan University of Chinese Medicine