Effect of Fuqingzhu Huodan Shenfang on Regulation of T Cell Subsets and Related Cytokines in Patients with Herpes Zoster

HAN Xiao-dong; WEN Xin; ZHANG Hai-xia; YANG Jing; HUANG Wei

doi:10.13422/j.cnki.syfjx.2017180198

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Effect of Fuqingzhu Huodan Shenfang on Regulation of T Cell Subsets and Related Cytokines in Patients with Herpes Zoster

更新时间：2024-01-04

- Effect of Fuqingzhu Huodan Shenfang on Regulation of T Cell Subsets and Related Cytokines in Patients with Herpes Zoster
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 18, Pages: 198-203(2017)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.2017180198
  CLC： R275.9
- Published：2017
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HAN Xiao-dong, WEN Xin, ZHANG Hai-xia, et al. Effect of Fuqingzhu Huodan Shenfang on Regulation of T Cell Subsets and Related Cytokines in Patients with Herpes Zoster[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(18): 198-203.
DOI：

HAN Xiao-dong, WEN Xin, ZHANG Hai-xia, et al. Effect of Fuqingzhu Huodan Shenfang on Regulation of T Cell Subsets and Related Cytokines in Patients with Herpes Zoster[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(18): 198-203. DOI： 10.13422/j.cnki.syfjx.2017180198.

摘要

目的：通过观察傅青主火丹神方对带状疱疹患者T细胞亚群及相关细胞因子的影响，探讨其临床疗效及机制。方法：选择136例带状疱疹患者随机分为观察组和对照组，每组68例。对照组予常规西药治疗，观察组加用傅青主火丹神方治疗，观察两组患者临床疗效，并测定比较两组患者治疗前后T细胞亚群，白细胞介素-4（IL-4），白细胞介素-6（IL-6），肿瘤坏死因子-α（TNF-α）水平，实时荧光定量PCR测定血清信号转导和转录激活因子3（STAT3），磷酸化-STAT3（p-STAT3） mRNA水平。结果：观察组的总有效率为97.1%，明显高于对照组的83.8%（χ2=5.146，P<0.05）。治疗后，两组患者的疼痛视觉（VAS）评分均较治疗前明显降低（P<0.05），观察组较对照组下降更为明显（P<0.05）。随访6个月，观察组的后遗神经痛发生率5.9%，明显低于对照组的26.5%（P<0.05）。治疗后，两组患者CD3+，CD4+细胞比例均较治疗前明显升高（P<0.05），观察组CD8+细胞明显降低（P<0.05），CD4+/CD8+明显升高（P<0.05），且高于对照组（P<0.05）。治疗后，两组患者IL-4，IL-6均较治疗前明显降低，TNF-α明显升高（P<0.05），观察组变化更加明显（P<0.05）。治疗前，两组患者的STAT3，p-STAT3在同一水平。治疗后，两组患者的STAT3，p-STAT3均较治疗前明显降低（P<0.05），观察组降低更加明显（P<0.05）。结论：在常规西药基础上，加用傅青主火丹神方治疗能更好的减轻临床症状，提高临床疗效，其机制可能通过调节机体免疫功能，减轻两面神激酶（Janus kinase，JAK）/STAT通路激活，减少炎症因子释放，并进一步减轻炎症反应有关。

Abstract

Objective: To explore the clinical effect and mechanism by observing the effect of Fuqingzhu Huodan Shenfang on the cell subsets and related cytokines in patients with herpes zoster.Method: The 136 cases of herpes zoster were randomly divided into observation group and control group

68 cases in each group. The patients in control group were treated with conventional western medicine

and patients in observation group were treated with FU Qing-zhu Huodan Shenfang based on the treatment in control group. Then the clinical efficacy of the two groups was observed

and T cell subsets

interleukin-4 (IL-4) and interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) levels before and after treatment were detected and compared between two groups

and serum STAT3

p-STAT3 levels were detected by Real-time PCR.Result: The total efficiency was 97.1% in observation group

significantly higher than 83.8% in control group (χ2=5.146

P<0.05). After treatment

the visual analogue scale(VAS) scores were significantly decreased in both groups (P<0.05)

and the decrease was more obvious in observation group (P<0.05). After 6 months of follow-up

the incidence of postherpetic neuralgia was 5.9% in observation group

significantly lower than 26.5% in control group (P<0.05). After treatment

the CD3+

CD4+ were significantly increased in both groups (P<0.05); the CD8+ count was significantly decreased (P<0.05) and CD4+/CD8+ was significantly increased in observation group

and the CD4+/CD8+ was higher than that in control group (P<0.05). After treatment

the IL-6

IL-4 levels were significantly decreased and TNF-α was significantly increased in both groups (P<0.05)

and the changes were more obvious in observation group (P<0.05). Before treatment

the STAT3 and p-STAT3 levels were at the same level in two groups

and after treatment

they were significantly decreased in both groups (P<0.05)

and the decrease was more obvious in observation group (P<0.05).Conclusion: On the basis of conventional western medicine

Fuqingzhu Huodan Shenfang can better reduce the clinical symptoms

improve clinical curative effect

and the mechanism may be relate to regulating immune function

inhibiting the JAK/STAT pathway

and reducing the inflammatory factors and inflammatory response.

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