Objective: To observe the effect of Liandou Qingmai recipe on atherosclerosis(AS) plaques of Japanese rabbits and poly adenosine diphosphate ribose polymerase-1 (PARP-1). Method: Totally 40 healthy male Japanese white rabbits were randomly divided into two groups. Among them

8 rabbits were randomly selected into blank group (Bg). The remaining 32 rabbits

according to the literature method

were selected to establish AS plaque model through feeding high fat diet and intravenous injection with bovine serum albumin. Finally

27 rabbits were successfully modeled and randomly divided into 3 groups:high-fat group included 11 rats (2 rats died during the experiment

HFg)

Liandou Qingmai recipe treatment group (LTg) included 8 rats

and simvastatin treatment group (STg) included 8 rats

which were given high-fat diet

Liandou Qingman recipe drug diet

simvastatin diet respectively

with the doses of 1 mg·kg-1·d-1 for simvastatin

and 3.7 g·kg-1·d-1 for Liandou Qingman recipe. After 8 weeks

AS plaques

PARP-1 positive expression

Toll like receptor-4 (TLR-4) mRNA expression

nuclear factor-kappa B (NF-κB)

serum interleukin-6 (IL-6) were detected. Result: The Bg did not appear AS plaque. The LTg's AS plaque significantly lower than that of the high-fat group. Compared with the Bg

the LTg's AS plaque area

aortic and tissue expressions of PARP-1 and TL-4 mRNA

levels of NF-κB and IL-6 increased. But compared with the HFg

the LTg's figures decreased. The differences were statistically significant (P<0.01). Conclusion: Liandou Qingmai recipe can inhibit the proliferation of AS plaque; the mechanism may be related to inhibition of the expression of PARP-1 and other inflammatory reactions.