Effect of Yisui Bushen Formula in Improving Malignant Lymphoma Chemotherapy-related Anemia and Immune Function

WANG Yong-min; ZHENG Xue-mei; LIU Ying; HU Dong-ju; XIAO Hui-ying; GUO Zi-jing

doi:10.13422/j.cnki.syfjx.2017190180

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Effect of Yisui Bushen Formula in Improving Malignant Lymphoma Chemotherapy-related Anemia and Immune Function

更新时间：2024-01-04

- Effect of Yisui Bushen Formula in Improving Malignant Lymphoma Chemotherapy-related Anemia and Immune Function
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 19, Pages: 180-185(2017)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.2017190180
  CLC： R733.1
- Published：2017
- 稿件说明：
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WANG Yong-min, ZHENG Xue-mei, LIU Ying, et al. Effect of Yisui Bushen Formula in Improving Malignant Lymphoma Chemotherapy-related Anemia and Immune Function[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(19): 180-185.
DOI：

WANG Yong-min, ZHENG Xue-mei, LIU Ying, et al. Effect of Yisui Bushen Formula in Improving Malignant Lymphoma Chemotherapy-related Anemia and Immune Function[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(19): 180-185. DOI： 10.13422/j.cnki.syfjx.2017190180.

摘要

目的：探讨益髓补肾方改善恶性淋巴瘤化疗患者相关性贫血临床疗效，观察其对免疫功能的影响。方法：选取河北省中医院血液病科2010年1月-2015年12月收治的恶性淋巴瘤化疗相关性贫血患者110例，按随机数字表法分为对照组和治疗组，各55例，对照组常规化疗；治疗组在常规化疗基础上予以益髓补肾方（1剂/d）口服治疗，治疗15 d为1疗程，共治疗2个疗程。两组采血测定血常规，记录生活质量，同时比较临床疗效及并发症。结果：对照组总有效率为69.09%，治疗组有效率为89.09%，治疗组优于对照组（P<0.05）；与治疗前比较，两组治疗后血红蛋白（Hb），血细胞比容（Hct），红细胞计数（RBC）含量升高（P<0.05），促红细胞生成素（EPO）含量降低（P<0.05）；治疗后躯体、角色、社会、情绪等指标评分升高（P<0.05）；治疗后与对照组比较，治疗组治疗后Hb，Hct，RBC含量较高，EPO含量降低，治疗后躯体、角色、社会、情绪等评分升高（P<0.05）；治疗组T淋巴细胞亚群CD3+，CD4+，CD4+/CD8+水平升高，CD8+细胞水平下降（P<0.05）；对照组不良反应发生率为12.73%，治疗组不良反应发生率为7.27%，治疗组低于对照组（P<0.05）。结论：益髓补肾方治疗恶性淋巴瘤化疗相关性贫血疗效确切，可提高生活质量及患者免疫功能，具有较好的增效减毒作用。

Abstract

Objective: To investigate the clinical effect of Yisui Bushen formula in improving malignant lymphoma chemotherapy-related anemia and immune function. Method: Totally 110 cases of malignant lymphoma chemotherapy-related anemia patients treated in our Haematology Department from January 2010 to December 2015 were selected and randomly divided into treatment group and control group according to random number table method

with 55 cases in each group. The control group was given conventional chemotherapy

while the treatment group was given Yisui Bushen formula for oral treatment (1/d) in addition to conventional chemotherapy. One course of treatment was 15 days

and they received 2 courses of treatment. Blood routine examination was performed

and the quality of life

clinical curative effect and complications of the two groups were observed and compared. Result: The total effective rate of the control group was 69.09%

whereas the total effective rate of the treatment group was 89.09%

indicating a statistically significant difference (P<0.05). Compared with before treatment

hemoglobin (Hb)

hematocrit (Hct)

red blood cell (RBC) content of the two groups increased after treatment (P<0.05)

while the recombinant human erythropoietin (EPO) content reduced

suggesting statistically significant differences (P<0.05). After treatment

scores of body

role

social

emotional

and other indicators were increased

indicating statistically significant differences (P<0.05). The effectiveness of treatment group was 87.80%

which was higher than 68.29% of control group (P<0.05). After treatment

the levels of CD3+

CD4+

CD4+/CD8+ and CD8+ cells in treatment group were significantly lower than those in control group (P<0.05). The incidence of adverse reactions of control group was 12.73%

whereas the incidence of adverse reactions of treatment group was 7.27%

indicating a statistically significant difference in adverse reactions between two groups (P<0.05). Conclusion: Yisui Bushen formula shows an obvious clinical effect in improving malignant lymphoma chemotherapy-related anemia

the quality of life and immune function

with good synergy and attenuation.

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