Preparation and Pharmacodynamic Analysis of Xiaobo Muti Oral Ulcer Film

WANG Ya-lei; GUO Peng-jie; WANG Tie-han; DING Jiao-li; LI Dan-yao; BAO Hai-ying

doi:10.13422/j.cnki.syfjx.2017200020

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Preparation and Pharmacodynamic Analysis of Xiaobo Muti Oral Ulcer Film

更新时间：2024-01-04

- Preparation and Pharmacodynamic Analysis of Xiaobo Muti Oral Ulcer Film
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 20, Pages: 20-24(2017)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2017200020
  CLC： R283.6
- Published：2017
- 稿件说明：
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WANG Ya-lei, GUO Peng-jie, WANG Tie-han, et al. Preparation and Pharmacodynamic Analysis of Xiaobo Muti Oral Ulcer Film[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(20): 20-24.
DOI：

WANG Ya-lei, GUO Peng-jie, WANG Tie-han, et al. Preparation and Pharmacodynamic Analysis of Xiaobo Muti Oral Ulcer Film[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(20): 20-24. DOI： 10.13422/j.cnki.syfjx.2017200020.

摘要

目的：以大叶小檗根和木蹄层孔菌子实体为原料，根据中药配伍理论，采用制剂学方法研制了小檗木蹄口腔溃疡药膜。方法：以成型性、外观、柔软度、韧性的综合评分为指标，选择淀粉、羧甲基纤维素钠、甘油、炼蜜用量为考察因素，通过正交试验优选小檗木蹄口腔溃疡药膜的配方。通过建立大鼠口腔溃疡动物模型进行了该膜剂的药效学研究，将大鼠随机分为空白组、模型组、阳性组、小檗木蹄口腔溃疡药膜高、中、低剂量组。阳性组用蜂胶口腔膜给药，每只每次1片，1 d内分2次给药。小檗木蹄口腔溃疡膜高剂量组1 d内分4次给药（4片）。小檗木蹄口腔溃疡膜中剂量组1 d内分2次给药（2片）。小檗木蹄口腔溃疡膜低剂量组每天1次给药（1片），均连续给药7 d。结果：膜剂最佳配方为大叶小檗提取物浸膏-木蹄层孔菌提取物浸膏-淀粉-羧甲基纤维素钠-甘油-炼蜜-水（8：4：10：2：3：20：500），此配方下，该药膜的各评价指标的评分为成型性23.6分，外观23.8分，柔软度22.5分，韧性23.3分。该膜剂对于治疗大鼠口腔溃疡效果明显，愈合率很高。结论：制得的小檗木蹄口腔溃疡药膜具有抑菌消炎、促进愈合的作用，治疗口腔溃疡效果明显。

Abstract

Objective: In this paper

taking Berberis amurensis root and Fomes fomentarius fruitbody as raw materials

based on the theory of compatibility of traditional Chinese medicine

the preparation method was used to develope Xiaobo Muti oral ulcer film. Method: Orthogonal test was adopted to optimize the formula of Xiaobo Muti oral ulcer film with comprehensive score of moldability

appearance

softness and toughness as index.Efficacy of the film was investigated by the establishment of rat oral ulcer animal model

female rats were randomly divided into blank group

model group

positive control group

high

medium and low dose group of Xiaobo Muti oral ulcer film.The positive control group was administered with propolis oral cavity membrane

one tablet each time

two times a day.The high dose group of Xiaobo Muti oral ulcer film was given 4 times within one day

4 tablets each time.The medium dose group of Xiaobo Muti oral ulcer film was administered 2 times a day

2 tablets each time.The low dose group of Xiaobo Muti oral ulcer film was administered once a day

one tablet each time.These all were given for a period of 7 days. Result: The best formula of Xiaobo Muti oral ulcer film was B. amurensis root extract-F. fomentarius fruitbody extract-starch-sodium carboxymethyl cellulose-glycerin-refining honey-water (8:4:10:2:3:20:500)

under this formula

the score of each index was as follows:23.6 points of moldability

23.8 points of appearance

22.5 points of softness

23.3 points of toughness. Conclusion: Xiaobo Muti oral ulcer film has antibacterial and anti-inflammatory

it can promote healing effect for treatment of oral ulcer significantly.B. amurensis root and F. fomentarius fruitbody can work together to compose prescription

which can enhance the effect of treatment of oral ulcer caused by the fire in the spleen

stomach and liver.

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