Objective: To observe and evaluate the clinical efficacy of Xiangsha Liujunzi Tang combined with acupuncture therapy in the treatment of syndrome of deficiency of spleen Qi and stomach Qi of functional dyspepsia and investigate its effect on motilin on plasma (MOT) and serum gastrin (GAS) levels. Method: The 120 cases of patients with syndrome of deficiency of spleen Qi and stomach Qi of functional dyspepsia from January 2014 to August 2016 in Department of Gastroenterology

Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine were selected as research subjects and were randomly divided into treatment group (62 cases) and control group (58 cases).The patients in treatment group received oral Xiangsha Liujunzi Tang combined with acupuncture therapy

and the patients in the control group were treated with itopride hydrochloride dispersible tablets combined with compound azimtamide enteric-coated tablets treatment.Both groups were treated for 2 courses

2 weeks/course.After the end of treatment

the patients with clinical recovery were followed up for 2 months.The two groups were observed and compared in traditional Chinese medicine(TCM) syndrome scores

the overall curative effect and the changes of plasma MOT and serum GAS levels

the Hamilton Anxiety Scale (HAMA) score and the 17 item Hamilton Depression Rating Scale (HAMD-17) score

adverse reaction and long-term curative effect. Result: After the treatment

TCM syndrome scores

HAMA scores and HAMD-17 scores in the treatment group were significantly lower than those in control group (P<0.05); the total effective rate of the treatment group was 88.71%

significantly higher than 74.14% in control group (P<0.05); the plasma MOT level was significantly higher than that of control group (P<0.05)

and the serum GAS level was significantly lower than that of control group (P<0.05).No obvious adverse reactions were found during the period of treatment in two groups; the relapse rate was 11.11% in treatment group

significantly lower than 44.44% in control group (P<0.05). Conclusion: The curative effect of Xiangsha Liujunzi Tang combined with acupuncture therapy in the treatment of syndrome of deficiency of spleen Qi and stomach Qi of functional dyspepsia can significantly increase the clinical efficacy

safety

improve the anxiety and depression of the patients

and can improve the long-term curative effect.Its mechanism may be related to increasing the level of plasma MOT and decreasing the levels of GAS.