Objective: To evaluate the clinical efficacy of iontophoresis therapy of Fuzitang combined with Shaoyao Gancaotang on non-specific low back pain (NLBP)cold dampness and blood stasis syndrome and investigate its effects on levels of interleukin-1β (IL-1β)

thromboxane 2 (TXB2)

6-keto prostaglandin Flα(6-Keto-PGFlα)

calcitonin gene related peptide (CGRP)

and vasoactive intestinal peptide (VIP). Method: One hundred and seventy-six patients were randomly divided into control group and observation group by random number table.Patients in control group received Yaotuitong pills+electroacupuncture

and patients in observation group received Fuzitang

Shaoyao Gancaotang combined with electroacupuncture.The treatment course was 4 weeks for both groups.Before and after treatment

scores of tenderness condition in simplified McGill pain scale (SF-MPQ) were graded

and the tenderness and pain thresholds were measured.functions were evaluated by using Japan orthopedics association (JOA) method

and patients' global impression of change (PGIC) and cold dampness and blood stasis syndrome were evaluated discussed.In addition

levels of IL-1β

TXB2

6-Keto-PGFlα

CGRP and VIP were detected

and safety evaluation was conducted. Result: The total amelioration rate of JOA was 95.18% in observation group

higher than 83.95% in control group (χ2=5.564

P<0.05).Scores of the pain feeling

pain emotion

visual analog pain

current pain conditions and total pain score in the observation group were all lower than those in control group (P<0.01).The hardness value

tenderness and traditional Chinese medicine (TCM) syndrome scores were lower than those in in control group

but pain threshold value was higher than that in control group (P<0.05 and P<0.01).Scores of subjective symptoms

clinical symptoms

limitation of daily activities

and the total sore of JOA scale in observation group were higher than those in control group (P<0.01).In addition

the markedly improved rate was 68.67% in observation group

higher than 50.62% in control group (χ2=5.558

P<0.05)

and the levels of IL-1β

TXB2

CGRP and VIP were lower than those in control group

while 6-Keto-PGFlα was higher than that in control group (P<0.01). Conclusion: Iontophoresis therapy of electroacupuncture combined with Fuzitang and modified Shaoyao Gancaotang can relieve patients' pain

promote the recovery of lumbar function and improve activity ability in the patients with non-specific low back pain with cold dampness and blood stasis syndrome.