JIN Peng, XU Hai-jian, XU Bao-xin, et al. Research Status of Baicalin and Prospect of Its Magnesium Salt[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(20): 228-234.
DOI:
JIN Peng, XU Hai-jian, XU Bao-xin, et al. Research Status of Baicalin and Prospect of Its Magnesium Salt[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(20): 228-234. DOI: 10.13422/j.cnki.syfjx.2017200228.
Research Status of Baicalin and Prospect of Its Magnesium Salt
Scutellariae Radix is the dried roots of Scutellaria baicalensis belonging to Labiataeae.It has been used as a medicine for a long time and mainly for the treatment of pulmonary cough
acute dysentery
irascibility and headache.In recent years
scholars at home and abroad have found that baicalin is one of the active ingredients contained in Scutellariae Radix
with anti-bacterial
anti-inflammatory
sedationand reducing blood pressure
protecting liver and gallbladder and other pharmacological effects.Magnesium
as one of the necessary elements that human body needs
plays an important role in the metabolism of the human body.This paper was to study the pharmacological effects and drug-preparations of baicalin and magnesium byreviewing relevant references in Wanfang
CNKI and PubMed databaseswithinrecent years.It was foundthat in addition toanti-inflammatory
anti-virus and anti-oxidation effects
baicalin was alsoeffective in the treatment of hepatitis and asthma
with anti-tumor andanti-human immunodeficiency virus(HIV)-1 activities
and it could promote the growth of embryonic in vitro.In addition
it also had protective effects on cerebral ischemia-reperfusion injury and diabetic nephropathy.However
the pharmacokinetic study of baicalin showed that it had poor water solubility and low absolute bioavailability.Researchers developed a number of new drug delivery systems to improve the bioavailability of baicalin.Previous studies had confirmed that the original form of baicalin in Scutellariae Radix was baicalin magnesium salt.In order to explore the possible pharmacological action of baicalin magnesium salt and the feasibility of its preparations
pharmacological effects and mechanism of baicalin and magnesium were summarized brieflyin this paper
and the future directions for baicalin magnesium salt pharmacological study and drug-preparations wereproposed
hoping toprovide references for the studyof baicalin magnesium salt and lay a foundation foritsdevelopment and clinical applications.
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Comparison of Intestinal Absorption Kinetics and Pharmacokinetics of Baicalin Magnesium Salt and Baicalin
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Related Author
Peng JIN
Jing LI
Cui-zhe LIU
LIU Yi-xin
LIU Xi-gang
CHANG Jin-hua
SONG Hong-ru
LI Ying
Related Institution
Hebei Province Key Laboratory of Research and Development for Chinese Medicine, Chengde Medical University
Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences
Guang'anmen Hospital, China Academy of Chinese Medical Sciences
Research Center for Differentiation and Development of Traditional Chinese Medicine (TCM) Basic Theory, Jiangxi Province Key Laboratory of TCM Etiopathogenisis, Jiangxi University of Chinese Medicine
Tianjin University of Traditional Chinese Medicine(TCM)