Objective: To compare the effect of different administration routes with Shuangjinlian mixture on exopathic fever of children. Method: A total of 122 children with exopathic fever were randomly divided into clysis group (62 cases) and oral group (60 cases). Clysis group was given Shuangjinlian mixture by clysis administration

while the oral group was treated with Shuangjinlian mixture by oral administration. Clinical curative effect

scores of traditional Chinese medicine (TCM) symptoms

interleukin (IL)-1β

interferon (IFN)-γ and tumor necrosis factor (TNF)-α levels in two groups

and average onset time of fever receding

average antipyretic time and average time of complete fever receding of two groups were observed. Result: The average onset time of fever receding

the average fever antipyretic time and the average time of complete fever receding of the clysis group were significantly shorter than those of oral group (P < 0.05). After treatment

IL-1β

IFN-γ

TNF-α levels in two groups were significantly decreased

with statistically significant differences (P < 0.05). And the two indicators in treatment group were significantly better than those in control group

with significant differences between two groups (P < 0.05). The curative effect of the clysis group was obviously superior to that of oral group (P < 0.05). Conclusion: Shuangjinlian mixture has a satisfactory clinical efficacy in treating pediatric exogenous fever. Clysis is an effective route of administration and good compliance among children patients

which were better than oral administration

and thus worth of clinical application. Therefore

clysis can be used as the first choice in treatment of children patients with exopathic fever.