Mechanism of Gongliuxiao Capsules on Angiogenesis in Patients with Endometriosis with Qi Stagnation and Blood Stasis Syndrome

ZHOU Yan; LIU Ming-zhu

doi:10.13422/j.cnki.syfjx.2017210200

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Mechanism of Gongliuxiao Capsules on Angiogenesis in Patients with Endometriosis with Qi Stagnation and Blood Stasis Syndrome

更新时间：2024-01-04

- Mechanism of Gongliuxiao Capsules on Angiogenesis in Patients with Endometriosis with Qi Stagnation and Blood Stasis Syndrome
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 21, Pages: 200-205(2017)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2017210200
  CLC： R271.9
- Published：2017
- 稿件说明：
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ZHOU Yan, LIU Ming-zhu. Mechanism of Gongliuxiao Capsules on Angiogenesis in Patients with Endometriosis with Qi Stagnation and Blood Stasis Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(21): 200-205.
DOI：

ZHOU Yan, LIU Ming-zhu. Mechanism of Gongliuxiao Capsules on Angiogenesis in Patients with Endometriosis with Qi Stagnation and Blood Stasis Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(21): 200-205. DOI： 10.13422/j.cnki.syfjx.2017210200.

摘要

目的：探讨宫瘤消胶囊治疗子宫内膜异位症（EMs）气滞血瘀证的临床疗效及对血管内皮生长因子（VEGF），基质金属蛋白酶（MMP），碱性成纤维细胞生长因子（bFGF），转化生长因子-β1（TGF-β1）和肿瘤坏死因子-α（TNF-α）等促血管生成因子水平的影响。方法：将128符合EMs气滞血瘀证患者，采用SAS软件生成的，随机按数字表法分为对照组和观察组各64例。两组患者均服用孕三烯酮胶囊，2.5 mg/次，2次/周，于月经第1 天开始，每周固定时间服药。观察组加服宫瘤消胶囊，4粒/次，3次/d。两组疗程均连续治疗6个月经周期。经期疼痛情况采用视觉模拟评分（VAS）评分，进行治疗前后非月经期的盆腔痛、性交疼痛、盆腔压痛、骶韧带触痛结节和气滞血瘀证评分；检测治疗前后血清癌抗原125（CA125），CA199，VEGF，MMP-2，MMP-9，bFGF，TGF-β1和TNF-α水平。结果：观察组临床总有效率为91.67%，高于对照组的76.27%（χ2=5.255，P < 0.05）；观察组在第4，5，6个月经周期VAS评分均低于对照组（P < 0.01）；治疗后观察组非月经期的盆腔痛、性交疼痛、盆腔压痛、骶韧带触痛结节评分均低于对照组（P < 0.01），观察组气滞血瘀证评分低于对照组（P < 0.01）；观察组患者血清CA125 和CA199水平均低于对照组（P < 0.01）；观察组患者血清VEGF，MMP-2，MMP-9，bFGF，TGF-β1和TNF-α水平均低于对照组（P < 0.01）。结论：宫瘤消胶囊治疗子宫内膜异位症气滞血瘀证患者，能显著缓解患者的疼痛相关症状，提高临床疗效，并能降低VEGF等促血管生成因子水平，从不同靶点抑制新生血管的形成，起到控制病情的作用。

Abstract

Objective: To discuss the clinical efficacy of Gongliuxiao capsules on endometriosis (EMs) with Qi stagnation and blood stasis syndrome and investigate their effect on levels of vascular endothelial growth factor (VEGF)

matrix metalloproteinases (MMP)

basic fibroblast growth factor (bFGF)

transforming growth factor-β1 (TGF-β1) and tumor necrosis factor-α (TNF-α). Method: One hundred and twenty-eight patients with Ems were randomly divided into control group and observation group by random number table

64 cases in each group. Two groups of patients were treated with Gestrinone capsules

2.5 mg/times

2 times/week

first days after menstruation

weekly fixed time medication. Patients in observation group got Gongliuxiao capsules

4 capsules/time

3 times/day. 6 menstrual cycles were course of treatment in both groups. Menstrual pain was recorded by visual simulation score (VAS)

and scores of non-menstrual pelvic pain

sexual intercourse pain

pelvic tenderness

sacral ligament tenderness nodules and blood stasis syndrome were graded before and after treatment. In addition

levels of carcinoembryonic antigen 125 (CA125)

CA199

VEGF

MMP-2

MMP-9

bFGF

TGF-β1 and TNF-α were detected before and after treatment. Result: The total effective rate was 91.67% in observation group

higher than 76.27% in control group (χ2=5.255

P < 0.05). At the 4th

5th

6th menstrual cycle

VAS in observation group was lower than that in control group (P < 0.01). Scores of non-menstrual pelvic pain

sexual intercourse pain

pelvic tenderness

sacral ligament tenderness nodules and blood stasis syndrome in observation group were all lower than those in control group after treatment (P < 0.01)

and scores of CA125

CA199

VEGF

MMP-2

MMP-9

bFGF

TGF-β1 and TNF-α were all lower than those in control group (P < 0.01). Conclusion: Gongliuxiao capsules can ameliorate pain-related symptoms

improve clinical efficacy

reduce levels of proinflammatory cytokines such as VEGF

and promote the formation of neovascularization from different targets to control the condition.

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