Mechanism of Aconiti Lateralis Radix Praeparata-Zingiberis Rhizoma in Treatment of Heart Failure Based on Network Pharmacology

LIU Xin-kui; WU Jia-rui; ZHANG Dan; ZHANG Xiao-meng

doi:10.13422/j.cnki.syfjx.2017210212

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Mechanism of Aconiti Lateralis Radix Praeparata-Zingiberis Rhizoma in Treatment of Heart Failure Based on Network Pharmacology

更新时间：2024-01-04

- Mechanism of Aconiti Lateralis Radix Praeparata-Zingiberis Rhizoma in Treatment of Heart Failure Based on Network Pharmacology
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 21, Pages: 212-219(2017)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.2017210212
  CLC： R285.5
- Published：2017
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LIU Xin-kui, WU Jia-rui, ZHANG Dan, et al. Mechanism of Aconiti Lateralis Radix Praeparata-Zingiberis Rhizoma in Treatment of Heart Failure Based on Network Pharmacology[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(21): 212-219.
DOI：

LIU Xin-kui, WU Jia-rui, ZHANG Dan, et al. Mechanism of Aconiti Lateralis Radix Praeparata-Zingiberis Rhizoma in Treatment of Heart Failure Based on Network Pharmacology[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(21): 212-219. DOI： 10.13422/j.cnki.syfjx.2017210212.

摘要

目的：探讨附子-干姜药对治疗心力衰竭的作用机制。方法：本研究首先构建心力衰竭相关的蛋白互作网络，然后选取附子-干姜药对含有的24个活性成分，预测其作用靶点，进而构建附子-干姜药对活性成分-预测靶点网络、构建与心力衰竭相关的附子-干姜药对活性成分-潜在靶点网络、进行基于京都基因与基因组百科全书（KEGG）的生物通路富集分析，研究附子-干姜药对治疗心力衰竭的作用机制。结果：与心力衰竭相关的附子-干姜药对活性成分-潜在靶点网络包含23个靶点，关键靶点涉及碳酸酐酶2（CA2），11-β-羟基类固醇脱氢酶1（HSD11B1），基质溶素-1（MMP-3），肽基脯氨酰顺反异构酶FKBP1A（FKBP1A），磷酸二酯酶4D（PDE4D），热休克蛋白90α（HSP90AA1）等。KEGG通路7条，主要涉及肾素-血管紧张素系统（Renin-angiotensin system）等。结论：本研究结果初步验证和预测了附子-干姜药对治疗心力衰竭的作用机制，并为进一步深入揭示其作用机制奠定了良好基础。

Abstract

Objective: To investigate the mechanism of Aconiti Lateralis Radix Praeparata-Zingiberis Rhizoma in the treatment of heart failure. Method: Protein-protein interaction network related to heart failure was constructed

and targets related to 24 active chemical components from Aconiti Lateralis Radix Praeparata-Zingiberis Rhizoma were predicted. Active compound-predicted target network

active compound-potential target network related to heart failure

and potential target-pathway network were constructed to explore the mechanism of Aconiti Lateralis Radix Praeparata-Zingiberis Rhizoma in the treatment of heart failure. Result: The active compound-potential target network of Aconiti Lateralis Radix Praeparata-Zingiberis Rhizoma related to heart failure contained 23 targets

in which key targets involved Carbonic anhydrase 2 (CA2)

Corticosteroid 11-beta-dehydrogenase isozyme 1 (HSD11B1)

stromelysin-1 (MMP-3)

peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A)

cAMP-specific 3

5-cyclic phosphodiesterase 4D (PDE4D)

and heat shock protein HSP 90-alpha (HSP90AA1). In Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis

there were 7 KEGG pathways

mainly involving Renin-angiotensin system. Conclusion: The findings preliminarily verify and predict the basic pharmacological effects and relevant mechanisms of Aconiti Lateralis Radix Praeparata-Zingiberis Rhizoma in the treatment of heart failure

in order to lay a solid foundation for further studies on the mechanism of Aconiti Lateralis Radix Praeparata-Zingiberis Rhizoma in the treatment of heart failure.

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