WANG Zhi-lei, LIU Su-juan, ZHANG Xin, et al. Research Progress of Biotransformation of Bioactive Flavonoids[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(21): 220-228.
DOI:
WANG Zhi-lei, LIU Su-juan, ZHANG Xin, et al. Research Progress of Biotransformation of Bioactive Flavonoids[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(21): 220-228. DOI: 10.13422/j.cnki.syfjx.2017210220.
Research Progress of Biotransformation of Bioactive Flavonoids
Flavonoids have a variety of pharmacological activities
including anti-inflammatory
anti-oxidation
anti-thrombosis
antibacterial
antiviral
and hypolipidemic
etc. As a commonly used safe edible fungi
Aspergillus niger is widely used in microbial transformation and plays an important role in the biotransformation of flavonoids. This paper reviews the progress of biotransformation of flavonoids and their derivatives in A. niger at home and abroad in recent 15 years in order to provide reference for the further development and application of A. niger. The results showed that the main types of flavonoids participated in biotransformation were flavone
flavonoid glycoside
flavanone
chalcone
polymethoxyflavonoids
and isoflavanone. Hydroxylation
dehydroxylation
methylation
demethylation
carbonylation
decarbonylation
glycosylation
and de-glycosylation were the main reactions. The transformation mechanism may be generated with enzyme involved
and would develop conversion products after the occurrence of the above reaction. The study on the progress of the transformation of flavonoids from A. niger was carried out not only to provide theoretical guidance for the application of A. niger to the actual production of flavonoids
but also lay the theoretical basis and reference for the microbial efficient transformation of chemical compositions with pharmacological activity.