Effect of Maxing Shigan Tang Combined with Azithromycin on Anti-inflammatory, Pro-inflammatory Cytokines and Immune Function of Mycoplasma Pneumonia Children

BIAN Hong-en; CHEN Tuan-ying; SHAN Hai-jun

doi:10.13422/j.cnki.syfjx.2017220177

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Effect of Maxing Shigan Tang Combined with Azithromycin on Anti-inflammatory, Pro-inflammatory Cytokines and Immune Function of Mycoplasma Pneumonia Children

更新时间：2024-01-04

- Effect of Maxing Shigan Tang Combined with Azithromycin on Anti-inflammatory, Pro-inflammatory Cytokines and Immune Function of Mycoplasma Pneumonia Children
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 22, Pages: 177-181(2017)
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- DOI：10.13422/j.cnki.syfjx.2017220177
  CLC： R725.6
- Published：2017
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BIAN Hong-en, CHEN Tuan-ying, SHAN Hai-jun. Effect of Maxing Shigan Tang Combined with Azithromycin on Anti-inflammatory, Pro-inflammatory Cytokines and Immune Function of Mycoplasma Pneumonia Children[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(22): 177-181.
DOI：

BIAN Hong-en, CHEN Tuan-ying, SHAN Hai-jun. Effect of Maxing Shigan Tang Combined with Azithromycin on Anti-inflammatory, Pro-inflammatory Cytokines and Immune Function of Mycoplasma Pneumonia Children[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(22): 177-181. DOI： 10.13422/j.cnki.syfjx.2017220177.

摘要

目的：探讨麻杏石甘汤联合阿奇霉素对小儿支原体肺炎（MPP）患者抗炎、促炎因子及免疫功能的影响。方法：选取河南中医药大学第二附属医院2014年11月—2016年4月收治的165例MPP患儿，按随机数字表法分为治疗组（83例）和对照组（82例）。对照组MPP患儿给予阿奇霉素序贯疗法进行治疗，治疗组联合麻杏石甘汤进行治疗。结果：治疗组患者总有效率为93.98%，对照组为81.71%，治疗组优于对照组（P<0.05）；与治疗前比较，治疗后，两组患儿血清中白细胞介素-2（IL-2）水平明显升高，且治疗组明显高于对照组（P<0.05），两组患儿白细胞介素-4（IL-4），白细胞介素-10（IL-10）水平明显降低，且治疗组明显低于对照组（P<0.05）；与治疗前比较，治疗后两组患儿血清中白细胞介素-6（IL-6），肿瘤细胞因子-α（TNF-α）与干扰素-γ（IFN-γ）水平明显降低，且治疗组低于对照组（P<0.05）；与治疗前比较，治疗后，两组患儿血清中CD3+，CD4+以及红细胞C3b受体（RBC-C3bR）水平明显升高，且治疗组明显高于对照组（P<0.05），CD8+与红细胞免疫复合物（RBC-ICR）水平明显降低，且治疗组明显低于对照组（P<0.05）；与治疗前比较，治疗后两组中医证候积分均有明显改善（P<0.05），与对照组相比，治疗组中医证候积分低于对照组（P<0.05），两组不良反应比较，差异无统计学意义。结论：麻杏石甘汤联合阿奇霉素治疗MPP患儿疗效显著，可能与其升高抗炎因子，降低促炎因子水平，改善患儿免疫功能有关。

Abstract

Objective: To study the effect of Maxing Shigan Tang combined with azithromycin on anti-inflammatory and pro-inflammatory cytokines and immune function of children with mycoplasmal pneumoniae pneumonia (MPP). Method: A total of 165 cases of children with MPP treated at our hospital from November 2014 to April 2016 were selected and divided into two groups according to the random number table

with 83 cases in clinical group and 82 in control group. Patients in control group were treated with azithromycin sequential therapy

while clinical group was given Maxing Shigan Tang combined with azithromycin sequential therapy. Result: The total effective rate of clinical group was 93.98%

which was 81.71% in control group

indicating that clinical group was superior to control group (P<0.05). Compared with before treatment

interleukin (IL)-4 and IL-10 of two groups were decreased

while IL-2 was increased after treatment (P<0.05). Compared with control group

the levels of IL-4 and IL-10 in patients of clinical group were lower

while IL-2 was higher after treatment (P<0.05). The levels of IL-6

tumor necrosis factor-α(TNF-α) and interferon-γ (IFN-γ) of two groups showed significant differences before and after treatment. The level of inflammatory factor in the clinical group was lower than in the control group (P<0.05). Compared with before treatment

CD8+and RBC-ICR of two groups were decreased

while CD3+

CD4+and RBC-C3bR were increased after treatment (P<0.05). Compared with control group

the levels of CD8+and RBC-ICR in patients of clinical group were lower

while CD3+

CD4+and RBC-C3bR were higher after treatment (P<0.05). Compared with control group

TCM syndrome score of clinical group was lower

with statistically significant differences (P<0.05). Conclusion: Maxing Shigan Tang is very effective in treating MPP children. It can significantly improve anti-inflammatory factors

reduce pro-inflammatory cytokines

and improve the immune function.

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