WANG Ren-jie, ZHANG Yan-jun, WANG Xing-xing, et al. Explore Latent Mechanism of Dracaenea Cochinchinensis Resina in Treating Ischemic Stroke by Using Knowledge-Discovery Tool Arrowsmith[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(22): 194-201.
DOI:
WANG Ren-jie, ZHANG Yan-jun, WANG Xing-xing, et al. Explore Latent Mechanism of Dracaenea Cochinchinensis Resina in Treating Ischemic Stroke by Using Knowledge-Discovery Tool Arrowsmith[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(22): 194-201. DOI: 10.13422/j.cnki.syfjx.2017220194.
Explore Latent Mechanism of Dracaenea Cochinchinensis Resina in Treating Ischemic Stroke by Using Knowledge-Discovery Tool Arrowsmith
Objective: To explore the potential mechanism of Dracaenea Cochinchinensis Resina in the treatment of ischemic stroke. Method: Online software of Arrowsmith based on the theory of Swanson's non-correlated literature-bases knowledge discovery was applied to explore the underlying mechanism by analyzing the intermediate words in the literature on Dracaenea Cochinchinensis Resina and ischemic stroke. Result: The preliminary investigation results by Arrowsmith software showed that Dracaenea Cochinchinensis Resina and its active components might have certain ability to regulate the expression levels of cyclooxygenase-2 (COX-2)
transient receptor potential vanilloid 1 (TRPV1)
nitric oxide synthase (NOS)
voltage-gated potassium channel 1.3 (Kv1.3) and transforming growth factor-β1 (TGF-β1); and these above indexes had abnormal expression in ischemic stroke. Conclusion: The mechanism may be associated with down-regulating the expression of COX-2 and iNOS
blocking TRPV1 and Kv1.3 channel
and promoting the expression of eNOS and TGF-β1.This can provide strong reference for the laboratory to conduct further mechanism verification studies.
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