Research Progress on Alkaloids of  Genus

FANG Zhong-ying; SU Si-yu; CAI Xiao-qing; FANG Lei; ZHANG Yong-qing

doi:10.13422/j.cnki.syfjx.2017220218

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Research Progress on Alkaloids of Genus

更新时间：2024-01-04

- Research Progress on Alkaloids of Genus
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 22, Pages: 218-225(2017)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2017220218
  CLC： R284.1
- Published：2017
- 稿件说明：
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FANG Zhong-ying, SU Si-yu, CAI Xiao-qing, et al. Research Progress on Alkaloids of Genus[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(22): 218-225.
DOI：

FANG Zhong-ying, SU Si-yu, CAI Xiao-qing, et al. Research Progress on Alkaloids of Genus[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(22): 218-225. DOI： 10.13422/j.cnki.syfjx.2017220218.

摘要

夹竹桃科（Apocynaceae）山橙属（Melodinus）植物在我国民间应用的历史悠久，常用于治疗小儿疝气、小儿疳疾、消化不良、腹痛、小儿脑膜炎、骨折和风湿性心脏病等，其化学成分及生物活性备受国内外学者的关注。生物碱类成分是该属植物重要的活性成分，现已从该属植物中分离到近200个构型新颖、结构复杂的生物碱类化合物。现代药理研究表明，山橙属植物具有抗肿瘤、抗菌、抗生育等生物活性，尤其对人白血病细胞（HL-60），肺癌细胞（A549），肝癌细胞（SMMC-7721），乳腺癌细胞（MCF-7）和结肠癌细胞（SW480）的抑制作用较明显，具有较高的研究价值。其化学成分和生物活性为当前研究的热点所在，但研究较为分散，缺少整体的综合归纳。该文结合近30年来的国内外文献，综合阐述了夹竹桃科山橙属植物中生物碱类成分的研究进展，分别对川山橙、薄叶山橙、尖山橙、思茅山橙、腋花山橙、景东山橙、雷打果和山橙等山橙属植物中吲哚生物碱和喹啉生物碱成分及其活性进行了综述，以期为山橙属植物的进一步开发利用提供参考。

Abstract

Apocynaceae Melodinus plants have a long history in folk use in China

and their chemical compositions and bioactivities are concerned by domestic and abroad scholars. As the important effective ingredients

more than 200 alkaloids with novel and complex structures have been isolated from Melodinus genus. According to the modern pharmacological studies

alkaloids of the Melodinus genus show good antitumor

antibacterial and antifertility activities. The studies on alkaloids of Melodinus genus were summarized according to the domestic and foreign literature in the past 30 years. The indole and quinoline alkaloids and their bioactivities were reviewed from M. hemsleyanus

M. tenuicaudatus

M. fusiformis

M. henryi

M. axillaris

M. khasianus

M. yunnanensis and M. suaveolens respectively to provide reference for further development of Melodinus plants.

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Related Institution

Jiangxi Provincial Key Laboratory of Pharmacology of Traditional Chinese Medicine

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School of Pharmacy， Jiangxi University of Chinese Medicine

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