Hederagenin is a pentacyclic triterpenoid isolated from plants. It is widely distributed in a variety of medicinal plants and is the main active ingredient of many natural products. The latest research progress on resource distribution

structural modification and pharmacological action of saponins of hederagenin was reviewed by integrating and analyzing the related literature at home and abroad

which provided the reference for further study on the structural modification and pharmacological action of hederagenin. Studies have shown that hederagenin is widely distributed in Dipsacaceae

Caprifoliaceae

Ranunculaceae

Araliaceae

Patrinia and other medicinal plants

rich in the natural resources. Hederagenin has a poor solubility

low bioavailability

poor oral administration effects and other characteristics

so that the clinical application of hederagenin is limited. Therefore

domestic and foreign scholars have made structural modifications which mainly occur in its C-28 position

C-3 position

C-23 position

C-12 position and C-13 position. The structural modification is more in C-28 position. Pharmacological activity studies have shown that hederagenin has anti-tumor

anti-depression

anti-bacterial

anti-inflammatory

anti-diabetes and other pharmacological effects

but its related mechanism is still lack of in-depth study. Through the systematic review of the resource distribution

structural modification and pharmacological action of the hederagenin

it can provide a reference for the deep research of hederagenin and provide a scientific basis for the safe and effective application of hederagenin and its derivatives.